Retrospective Study on Microbial Diversity in Paraffin Tissue of Pancreatic Diseases

The great harm of pancreatic diseases and the unknown etiology and pathogenesis make it difficult to intervene in most early cases in time. Previous studies by scholars and applicants at home and abroad have shown that the microflora in pancreatic tissue is closely related to chronic pancreatitis and pancreatic cancer. However, the research on the mechanism of microbial diversity in pancreatic tissue and the occurrence and development of various pancreatic diseases has not been reported. Based on the previous research, this subject continues to take various pancreatic diseases as the research object based on the database of pancreatic center and pathology department of Ruijin Hospital Affiliated to Medical College of Shanghai Jiaotong University, To explore the characteristics of microbial flora in pancreas in different pancreatic diseases and its mechanism of influence on disease microenvironment. Select specific microbial flora or targets in the pancreas for various pancreatic diseases, so as to provide new theoretical basis and practical guidance for the early diagnosis and treatment of pancreatic diseases.

Sex

All

Minimum age

5 Years

Maximum age

85 Years

Inclusion Criteria:

* Age ≥ 5 years old, ≤ 85 years old;
* After MDT discussion, routine surgery can be performed, and the postoperative pathology is clear as pancreatic cancer and other pancreatic diseases;
* No history of antibiotics for three months before surgery, no history of yogurt containing probiotics
* There is no serious damage to heart, liver and kidney function.

Exclusion Criteria:

* Antibiotics or yogurt containing probiotics history in three months;
* Patients with evidence of sensory or motor neuropathy;
* Those who have a clear cardiovascular disease, severe associated disease or active infection, including known HIV infection;
* Those who have a history of other cancers.