Clinical trial · Interventional
Less Than 100 Hours Hospital Stay After Pancreatico-duodenectomy, RCT
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Few decades back pancreatico-duodenectomy (PD) was associated with a very high morbidity and mortality. With recent advancements in surgical and anesthetic techniques and improvement in peri-operative care, PD has evolved into a procedure with acceptable morbidity and mortality. Today PD is associated with a mortality of less than 5%, in high volume tertiary care centers. The multimodal concept of fast-track surgery was first introduced in colonic surgery. Several studies have demonstrated the effectiveness of this program in colonic resection. Recently, fast-track surgery has been attempted in pancreatic surgery with encouraging results, but such data are sparse. The core aims of ERAS protocols are to safely hasten postoperative recovery and ease the stress response. Specifically, in the context of pancreatico-duodenectomy, such interventions have been shown to be safe with no increase in mortality or unplanned readmissions, delayed gastric emptying (DGE), or pancreatic fistula . Purported benefits include reduced admission related costs, incidence of DGE, overall morbidity and length of stay. The aim of this study was to evaluate the feasibility of implementing fast track rehabilitation protocol following pancreaticoduodenectomy and to see if it is associated with improved recovery, reduced morbidity and reduced length of hospital stay.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pancreas Cancer | Pancreatic Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Conventional Care | Other | — | UNRESOLVED |
| Fast track Care pancreatico-duodenectomy. | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Group A
- description
- Fast track Care (Enhanced recovery after)pancreatico-duodenectomy
- interventionNames
- Other: Fast track Care pancreatico-duodenectomy.
- type
- ACTIVE_COMPARATOR
- label
- Group B
- description
- Conventional Care pancreatico-duodenectomy.
- interventionNames
- Other: Conventional Care
Primary outcomes (1)
- measure
- Feasibility of enhanced recovery after pancreatico-dudenectomy
- timeFrame
- 1 month after surgery
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * Age ≤ 75 years * ASA 1 or 2 * BMI \< 35 * The underlying pathology or use of neoadjuvant chemotherapy did not preclude inclusion into the study Exclusion Criteria: \- pancreatico-duodenectomy with vascular reconstruction.
References
Publications (1)
- DERIVEDDebakey Y, Mostafa MS, Refaat A, Sheier SS, Nofal A. ERAS enables safe </= 100-hour discharge after pancreatoduodenectomy: a multicenter cohort study. Langenbecks Arch Surg. 2026 Jun 26;411(1):172. doi: 10.1007/s00423-026-04088-1. PMID 42360327