Clinical trial · Observational
ZOOMit-fMRI Identifies Language Functional Cortex
The Application of ZOOMit-fMRI to Identify Language Functional Cortex
NCT05188534CI-TRIAL-00055932unknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This Study was designed to collect a series of patients with gliomas which were involved in language related cortex to analyze difference accuracy of language related cortex localization between BOLD-fMRI and ZOOMit-fMRI.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Glioma | Glioma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (2)
- label
- BOLD-fMRI
- description
- Identifying the language functional cortex in glioma patients with BOLD-fMRI
- label
- ZOOMit-fMRI
- description
- Identifying the language functional cortex in glioma patients with ZOOMit-fMRI
Primary outcomes (1)
- measure
- The accurate rate for language related cortex localization with BOLD-fMRI and ZOOMit-fMRI
- timeFrame
- From scanning with BOLD-fMRI and ZOOMit-fMRI to getting the overlap indexes,assessed up to 2 weeks in each patient.
- description
- To illustrate the accurate rate of language functional cortex localization, the overlap indexes in BOLD-fMRI or ZOOMit-fMRI will be calculated. The results in BOLD-fMRI and ZOOMit-fMRI will be defined with 300 maximum value voxels via Statistical Parametric Mapping 8 (SPM8) software. According to the photographs and records of direct cortical stimulation (DCS) during awaken craniotomy, the DCS results will be confirmed as a global region with 5 mm diameter. Subsequently, the overlap of the BOLD-fMRI/ZOOMit-fMRI and DCS results will be calculated. In this way, the overlap indexes can be calculated as a ratio between the number of voxels overlapping and the number of total voxels in BOLD-fMRI and ZOOMit-fMRI. We defined if the overlap index is larger than 0, the localization result is accurate. In contrast, if the overlap index is equal to zero, the localization result is inaccurate. Finally, the accurate rate of language functional cortex localization can be calculated.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: 1. age ≥ 18 years; 2. no history of surgical treatment or radiotherapy; 3. no contraindication to MRI scanning; 4. agreeable to receive the fMRI scanning and awake craniotomy with DCS Exclusion Criteria: 1. basing on the anatomic MRI, the distance from the tumor to the hand-knob area lower than 20 mm; 2. disable to finish the task of clenching fist during fMRI scanning.
References
Publications (0)
Data not yet available
No reference posted for this study.