Clinical trial · Observational
Patient-derived Organoids Predicts the Clinical Efficiency of Colorectal Liver Metastasis
The Exploratory Study of Patient-derived Organoids for the Prediction and Evaluation of Clinical Efficiency Effect of Colorectal Cancer Liver Metastasis
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Accumulating evidence indicates that patient- derived organoids (PDOs) can predict drug responses in the clinic. Metastasis is the main cause of death in colorectal cancer patients, and the treatment of patients with liver metastasis remains poor. Tumor heterogeneity is the cause of treatment failure. In this study, we aim the investigate the consistency of drug sensitivity for the matched primary and metastatic tumor in patients with liver metastasis.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Explore the Consistency of Drug Sensitivity Between Primary Colorectal Cancer and Liver Metastases | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- The consistency of drug sensitivity
- timeFrame
- 3 years
- description
- To test the consistency of drug sensitivity of primary tumor and its matched liver metastasis
Secondary outcomes (1)
- measure
- The establishment of PDO
- timeFrame
- 3 years
- description
- To test the rate of PDO derived from primary and matched metastatic colorectal cancer .
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: * Histologically proven colorectal cancer with liver metastasis * Aged between 18 and 70 years * Written informed and signed consent * Accessible to surgery sample of metastasis and primary tumor Exclusion Criteria: * Less than 18 years and older than 70 years * Not able to give informed consent * Not accessible to surgery sample
References
Publications (0)
Data not yet available