Clinical trial · Observational
Predictive Models of Hepatic Decompensation and Survival Outcomes in Pediatric Patients With Cirrhosis
NCT05181332CI-TRIAL-00056063unknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The aim of this study was to developed and validated models to predict hepatic decompensation and survivals in pediatric patients with cirrhosis and compared these models with currently available models.
Conditions
Conditions (7)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Autoimmune Hepatitis | — | UNRESOLVED | — |
| Biliary Atresia | — | UNRESOLVED | — |
| Choledochal Cyst | — | UNRESOLVED | — |
| Cirrhosis | — | UNRESOLVED | — |
| HBV | — | UNRESOLVED | — |
| HCV | — | UNRESOLVED | — |
| Primary Sclerosing Cholangitis | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Prediction model | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Retrospective cohort
- description
- The internal cohort was retrospectively enrolled in West China Hospital, Sichuan University from June 2010 and December 2020. It is a training and internal validation cohort.
- interventionNames
- Other: Prediction model
- label
- Prospective cohort
- description
- The same inclusion/exclusion criteria were applied for the same center prospectively. It is a external validation cohort.
- interventionNames
- Other: Prediction model
Primary outcomes (1)
- measure
- Hepatic decompensation
- timeFrame
- At least 5-year follow up
- description
- The primary outcome was the first event of hepatic decompensation, defined by the occurrence of any of the following: ascites (identified or confirmed by abdominal ultrasound), upper gastrointestinal bleeding secondary to portal hypertension (confirmed by endoscopy in the presence of gastroesophageal varices or portal hypertensive gastropathy), or hepatic encephalopathy (established by clinical parameters, neuropsychological tests, or electroencephalogram)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 0 Years
- Maximum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Age up to 18 years old * No previous episodes of clinical decompensation * With written informed consent Exclusion Criteria: * Clinical data missing * Without written informed consent
References
Publications (0)
Data not yet available
No reference posted for this study.