Aesthetic Outcomes of Oncoplastic Breast Surgery for Breast Cancer in the Upper Inner Quadrant

Inclusion Criteria:

* Signed the informed consent.
* Female aged between 18 and 70 years.
* Pathologically diagnosed operable breast cancer.
* WHO Eastern Cooperative Oncology Group (ECOG) performance status of 0-1.
* Cancer located in the upper inner quadrant; Single tumor or multiple tumors in the same quadrant.
* The important organ functions meet the following criteria:
* WBC \>=3.0 x 10\^9/L; Neutrophilic granulocytes \>=1.5×10\^9/L; Platelet \>=100 x 10\^9/L; Hb \>=9 g/dL;
* Total bilirubin no more than 1.5 times the normal upper limit (ULN); AST and ALT no more than 1.5 times ULN; AKP no more than 2.5 times ULN;
* Serum creatinine no more than 1.5 times ULN or Clearance rate of creatinine \>= 60ml/min;
* Thyroid stimulating hormone (TSH) \<= ULN (T3, T4 levels need to be detected simultaneously if abnormalities, the patient can be included if T3, T4 levels is normal);
* LVEF basement \>= 50%.
* Adjust to the criteria of breast conserving surgery.

Exclusion Criteria:

* Multifocal or multicentric disease.
* Tumor localized in the central quadrant or the distance to the nipple \< 2 cm；
* Diffused calcifications with fine plemorphic or fine linear or fine-linear branching morphology.
* The ratio of tumor to breast \> 20%;
* The diameter of tumor is up to 4 cm;
* Women in the early or intermediate stage of pregnancy;
* Prior history of breast radiation;
* Any severe comorbidities, inability to give informed consent or unavailability for follow-up.