Clinical trial · Interventional
Evaluation of Novel Cone-Beam CT for Guidance and Adaptation of Precision Radiotherapy
NCT05176860CI-TRIAL-00123918completedN/AResults postedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is a feasibility study investigating the image quality of a new, high-performance cone beam CT (CBCT) used for on-couch imaging during radiotherapy treatments.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
| Liver Cancer | Malignant Liver Neoplasm | CURATED_EXACT | 0.92 |
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
| Other Cancer | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| CBCT Imaging | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- High-performance CBCT imaging
- description
- Two additional study imaging sets are acquired.
- interventionNames
- Device: CBCT Imaging
Primary outcomes (5)
- measure
- CBCT Image Quality - Artifact Index
- timeFrame
- 1 day
- description
- Artifact Index (AI) is a measurement of the strength of imaging artifact and the degree to which is affects visibility of anatomical structures in the vicinity of the artifact. Artifacts can be produced in CT and CBCT images by a number of factors, such as metal implants, gas, or breathing motion. AI = sqrt((STD\_VOI)\^2 - (STD\_background)\^2), where STD\_VOI is the standard deviation of the image Hounsfield Units in a region of interest at the location of an artifact, and STD\_background is the standard deviation of the Hounsfield Unit values in the background (i.e. in similar tissue but away from the artifact. A lower AI value indicates that the artifact has a lower impact on image quality. Artifacts were identified in all study participants. The median AI across the study population is presented for four imaging modalities.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 19 Years
Show eligibility criteria text
Inclusion Criteria: * Subject is scheduled for treatment on one of the five TrueBeam platforms at the NS Health QE2 site. * Subject is receiving radiation therapy using a breath-hold technique (for example, lung, liver and left breast cancers). Exclusion Criteria: * Patient is pregnant or has plans for pregnancy during the period of treatment. * Patient is unwilling to consent to participating to the study, or for whom informed consent is not possible.
References
Publications (0)
Data not yet available
No reference posted for this study.