Clinical trial · Interventional
Nefopam as a Multimodal Analgesia for Thoracic Surgery
Nefopam as a Multimodal Analgesia for Video-assisted Thoracoscopic Surgery
NCT05173337CI-TRIAL-00063915completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Acute postoperative pain after video-assisted thoracoscopic surgery is very severe. Because pain after thoracic surgery prevents early recovery, and increases postoperative complications, its is important to prevent pain after video-assisted thoracoscopic surgery. In the present study, we will evaluate whether nefopam reduces pain after video-assisted thoracoscopic surgery.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Nefopam | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- NO_INTERVENTION
- label
- control group
- description
- Nefopam will not be administered in this group.
- type
- EXPERIMENTAL
- label
- nefopam group
- description
- Intravenous nefopam 20 mg will be administered twice, immediately after induction of anesthesia and at the end of surgery.
- interventionNames
- Drug: Nefopam
Primary outcomes (4)
- measure
- Pain after 1 hour of surgery
- timeFrame
- 1 hour after surgery.
- description
- Acute postoperative pain will be assessed using numerical rating scale from 0 (no pain) to 10 (worst pain ever).
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * patient scheduled for elective video-assisted thoracoscopic surgery * American Society of Anesthesiologists physical grade I, II, III * patient aged from 18 years old Exclusion Criteria: * history of allergy in nonsteroidal anti-inflammatory drugs, or nefopam * renal insufficiency * liver insufficiency * myocardial infarction * glaucoma * pregnant and lactating women at the time of surgery * patient who did not consent to the use of patient-controlled analgesia
References
Publications (1)
- DERIVEDKi HS, Shim JG, Choi HK, Ryu KH, Kang DY, Park J, Ahn JH, Lee SH, Cho EA. Nefopam as a multimodal analgesia in thoracoscopic surgery: a randomized controlled trial. J Thorac Dis. 2024 Jun 30;16(6):3644-3654. doi: 10.21037/jtd-24-30. Epub 2024 Jun 12. PMID 38983158