Clinical trial · Observational
Primary Tumour Response to Induction Chemotherapy in Synchronously Metastasized Colorectal Cancer
NCT05172635CI-TRIAL-00055701completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
We performed a retrospective data analysis of patients with synchronously metastasized colorectal cancer, comparing the histological response on the primary tumour to chemotherapy combined with either vascular endothelial growth factor (VEGF) or epidermal growth factor receptor (EGFR) inhibition.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Gastrointestinal Neoplasm | Digestive System Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (2)
- label
- Patients, who received a VEGF antibody
- description
- We distinguished between patients who received a VEGF antibody therapy and patients who received a EGFR antibody therapy.
- label
- Patients, who received a EGFR antibody
- description
- We distinguished between patients who received a VEGF antibody therapy and patients who received a EGFR antibody therapy.
Primary outcomes (1)
- measure
- Pathological response of the primary tumour
- timeFrame
- Tumour regression was assessed in the surgical specimen 3 to 7 days after surgery.
- description
- Investigation of the tumour response of the primary tumor (colorectal carcinoma) using the Rödel Score (tumour regression score)
Secondary outcomes (4)
- measure
- Pathological response of the liver metastases
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * older than 18 years * synchronously hepatic metastasized patients with colorectal carcinoma * indication of surgical treatment Exclusion Criteria: * younger than 18 years * metachronously metastasized patients
References
Publications (0)
Data not yet available
No reference posted for this study.