Persistent SARS-CoV-2 Infection in Children With Cancer and Impaired Immune Responsiveness

The main goal of this study is to characterize the adaptive immune responses to SARS-CoV-2 infection in a cohort of children with cancer and impaired immune responsiveness and prolonged viral shedding of SARS-CoV-2, and to identify SARS-CoV-2 variants that might arise during poorly controlled virus replication

Sex

All

Minimum age

1 Year

Maximum age

18 Years

Inclusion Criteria:

1. Children (\<18) of both genders undergoing cancer chemotherapy
2. Symptomatic SARS-CoV-2 infection, confirmed by (positive PCR test).
3. Patients with hematologic malignancies (ALL, AML, HL \& NHL) on active treatment or under follow up \< 3 months from end of treatment protocol

Exclusion Criteria:

1. Children (\<18 years) of both genders undergoing cancer chemotherapy with (PCR negative) test result for SARS-CoV-2.
2. Children who are PCR positive but are diagnosed with an immune disorder that may confound the study results.

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