Clinical trial · Interventional
Research of Laser Ablation for the Treatment of Lower Anogenital Tracts' Precancerous Lesions
Research of Multiple Targeting CO2 Laser Ablation for the Treatment of Lower Anogenital Tracts' Precancerous Lesions
NCT05170620CI-TRIAL-00055686unknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Using multiple targeting CO2 laser ablation to treat the precancerous lesion of the female lower anogenital tracts and analyzing the data collected in the study, we aim to form the standard strategy of laser ablation method to increase the effective rate and lower the rate of relapse and progression.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Laser Burn | — | UNRESOLVED | — |
| Squamous Intraepithelial Lesions | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| laser ablation | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Patients
- description
- Patients with squamous intraepithelial lesions of the lower anogenital tracts will receive laser ablation.
- interventionNames
- Procedure: laser ablation
Primary outcomes (1)
- measure
- Pathological cure
- timeFrame
- up to at least two years
- description
- No squamous intraepithelial lesions found by pathological examinations.
Secondary outcomes (1)
- measure
- HPV clearance
- timeFrame
- Every six months after initial treatment for at least two years
- description
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 16 Years
Show eligibility criteria text
Inclusion Criteria: 1. Had the history of sexual life. 2. Transferred to colposcopy examination and biopsy for abnormal screening of cervical cancer, contact bleeding of cervix, recurrent discomfort of vulva or abnormal signs of lower genital and anal tract. The pathology of biopsy indicate CIN, VaIN, VIN, AIN, or PaIN. 3. If CIN, the colposcopy manifests transformation zone-1 which means the lesion can totally be seen. However the consideration of fertility damage of resection overweighs the chance of suffering cancer. 4. The patients can accept multiple laser ablations and colposcopy examinations and follow-up at least 2 years. Exclusion Criteria: 1. Patients who are suffering cancers of other systems and in treatment. 2. Patients suffering acute inflammation of lower genital and anal tracts. 3. The colposcopy and pathology examination suspect of cancer of lower genital and anal tract. 4. Patients suffering severe diseases such as insufficiency of liver and kidney function, diseases of blood system and other acute infections who will get heath harm from colposcopy and laser vaporization.
References
Publications (0)
Data not yet available
No reference posted for this study.