Value of ctDNA in the Treatment of Multiple Primary Cancers

Inclusion Criteria:

* Patients who were assessed to meet the diagnostic criteria for multiple primary tumors : each tumor had to be invasive histologically
* Each tumor has its own pathologic appearance
* Each tumor occurs in a different organ and must exclude metastasis or recurrence
* progress or failure after treatment on a standard regimen for related primary cancer
* regardless of gender, between 18 and 75
* The Eastern Cancer Collaboration Group (ECOG) scored 0 \~ 1 in physical condition (PS)
* has an estimated survival of more than three months;
* During 7 days (including 7 days) before screening, the laboratory test data were obtained: neutrophil count ≥1.5×109/L, platelet count ≥90×109/L, hemoglobin ≥90g/L (no transfusion within 14 days), serum total bilirubin ≤1.25 times normal upper limit (ULN);alanine aminotransferase (ALT) and aspartate aminotransferase (AST)≤ 2.5 x ULN (≤5x ULN in patients with liver metastasis);Serum creatinine ≤1.25 x ULN and creatinine clearance ≥60ml/min;
* Participating subjects (or their legal representative/guardian) had to sign an informed consent form saying they understood the study's objectives, understood the required procedures, and were willing to participate in the study.

Exclusion Criteria:

* have standard treatment for metastatic disease;
* Participants were given any experimental or antineoplastic drugs during the first four weeks of enrollment;
* Either symptomatic brain or meningeal metastasis (unless the patient is treated for something)At 6 months, imaging results were negative within 4 weeks prior to study entry and tumor-related clinical symptoms were stable at study entry);
* clinically active bleeding;
* Women who are pregnant or breastfeeding;Those who are fertile but do not take adequate contraceptive measures;
* addicted to alcohol or drugs;
* either major organ failure or other serious illness, including interstitial pneumonia, clinically relevant coronary disease, cardiovascular disease, or having myocardial infarction, congestive heart failure, unstable angina, pronounced pericardial effusion, or unstable arrhythmia in the first 6 months of the study;
* A history of severe neurological or mental illness;Severe infection;Active disseminated intravascular coagulation or other comorbidities that, in the investigator's judgment, seriously compromised the patient's safety or prevented the patient from completing the study.