Clinical trial · Interventional
The Role of Interventional Pulmonology, Microbiota and Immune Response in the Patient With Lung Cancer
Observational Participants Not Assigned to Intervention(s) Based on a Protocol; Typically in Context of Routine Care
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study is designed to evaluate complications, specificity, diagnostic yield of radial endobronchial ultrasound guided transbronchial cryobiopsy and transbronchial forceps biopsy with fluoroscopy in the diagnosis of peripheral pulmonary lesion; the interplay between non-small-cell lung cancer associated-bacteria along the gut-lung axis and immune response in the cancer microenvironment.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Transbronchial forceps biopsy | Diagnostic Test | — | UNRESOLVED |
| Transbronchial forceps biopsy+Transbronchial cryobiopsy | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Transbronchial forceps biopsy
- description
- Patients, whose transbronchial forceps biopsy was performed
- interventionNames
- Diagnostic Test: Transbronchial forceps biopsy
- type
- ACTIVE_COMPARATOR
- label
- Transbronchial forceps biopsy+Transbronchial cryobiopsy
- description
- Patients, whose transbronchial forceps biopsy and transbronchial cryobiopsy were performed as well
- interventionNames
- Diagnostic Test: Transbronchial forceps biopsy+Transbronchial cryobiopsy
Primary outcomes (1)
- measure
- progression-free survival
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 90 Years
Show eligibility criteria text
Inclusion Criteria: * patients with peripheral lung lesion suspected of lung cancer detected on the chest computed tomography (CT) and RP-EBUS scans * Control group - patients without non-small cell lung cancer * Written (signed) Informed Consent to participate in the study Exclusion Criteria: * severe hypoxemia (partial pressure of oxygen (pO2)\< 60 mmHg) or hypercapnia (carbon dioxide partial pressure (pCO2)\> 50 mmHg), * bleeding disorders * The diffusing capacity for carbon monoxide (DLCOc)\< 35 %, * forced expiratory volume in one second (FEV1) \< 800 ml or FEV 1 \< 30 %, * peripheral lung tumor was not visualised by RP-EBUS longer than 30 minutes * large vessels (more than 3 mm) near the tumor on the CT scan, * technically difficult to introduce cryoprobe and/or endobronchial blocker to current bronchi segment or subsegment, * excessive bleeding after transbronchial forceps biopsy, which was needed extra intervention to stop bleeding.
References
Publications (0)
Data not yet available