Clinical trial · Observational
Microsatellite Instability in Colorectal Cancers
Clinicopathological Outcomes of Microsatellite Instability in Colorectal Cancer
NCT05162248CI-TRIAL-00055571MSI-CRCcompletedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
In this study, we aimed to identify the different histopathological features of tumors with microsatellite instability (MSI) compared to microsatellite stable (MSS) in patients who underwent surgery for colorectal cancer. We also planned to determine how MSI affects prognostic parameters.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
| Colorectal Carcinoma | Colorectal Carcinoma | ONTOLOGY_EXACT | 0.98 |
| Microsatellite Instability High | — | UNRESOLVED | — |
| Microsatellite Instability Low | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Microsatellite instability analysis | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Microsatellite instability
- description
- Immunohistochemical analysis was performed for Microsatellite Instability (MSI) status of colorectal tumors tissue.
- interventionNames
- Diagnostic Test: Microsatellite instability analysis
Primary outcomes (2)
- measure
- Overall Survival
- timeFrame
- Five years
- description
- Overall survival is defined as the time interval from the time of primary operation to the date of all-cause death or the last follow-up.
- measure
- Disease-Free Survival
- timeFrame
- Five years
- description
- Disease-Free Survival is defined as the time interval from the time of primary operation to disease recurrence or death.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 100 Years
Show eligibility criteria text
Inclusion Criteria: * Colorectal surgery patients * Complete follow-up information Exclusion Criteria: * Whose MSI status was not studied in the pathology material * Missing follow-up information * Colorectal resection for non-neoplastic diseases
References
Publications (3)
- BACKGROUNDSung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021 May;71(3):209-249. doi: 10.3322/caac.21660. Epub 2021 Feb 4. PMID 33538338
- BACKGROUNDGupta R, Sinha S, Paul RN. The impact of microsatellite stability status in colorectal cancer. Curr Probl Cancer. 2018 Nov;42(6):548-559. doi: 10.1016/j.currproblcancer.2018.06.010. Epub 2018 Jul 18. PMID 30119911
- BACKGROUNDBoland CR, Goel A. Microsatellite instability in colorectal cancer. Gastroenterology. 2010 Jun;138(6):2073-2087.e3. doi: 10.1053/j.gastro.2009.12.064. PMID 20420947