Clinical trial · Observational
Association of Salivary Amino Acid Level With OSCC Identified By Liquid Chromatography Mass Spectroscopy
Association of Salivary Amino Acid With Oral Squamous Cell Carcinoma Identified by Liquid Chromatography Mass Spectroscopy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Oral Squamous Cell Carcinoma (OSCC) is the most common oral malignancy worldwide. The prognosis of the OSCC patient is not significant despite the modern treatment facilities. Late presentation is one of the most crucial cause of this and for that reason, the importance of early diagnosis of OSCC should be the main concern. Till now, incisional biopsy followed by histopathological examination is the gold standard for diagnosis of oral cancer. The aim of the present study is to find out the association of salivary amino acid levels with oral squamous cell carcinoma, whether the levels are increased or decreased in the patient suffering from OSCC. This might be helpful for early diagnosis of oral cancer and better prognosis.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Oral Squamous Cell Carcinoma | Oral Cavity Squamous Cell Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Oral Squamous Cell Carcinoma | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Patients with Progressive Disease and without Progressive Disease
- description
- 1. Patients with Progressive Disease Patients with metastasis and/or recurrent OSCC were considered as a group of subjects with progressive disease. 2. Patients with without Progressive Disease Patients without metastasis and/or recurrent OSCC were considered as a group of subjects without progressive disease.
- interventionNames
- Diagnostic Test: Oral Squamous Cell Carcinoma
Primary outcomes (1)
- measure
- The primary outcome of the study to establish a diagnostic test in the early detection of OSCC.
- timeFrame
- From December,2020 to February, 2022
- description
- 1\. Total 110 samples, 55 in each group (case and control) will be included in the study and a questionnaire will be filled up by each participant based on their sociodemographic characteristics, personal habit and also the tumor staging of confirmed cancer cases. Saliva metabolite profiling of six amino acids (Alanine, Valine, Glycine, Phenylalanine, Isoleucine, Lysine) will be performed using LCMS/MS system. During metabolite profiling experiments, centroid data will be acquired for each sample from 50 to 1000 Da with a 0.10-sec scan time and a 0.01-sec interscan delay over an 18-min analysis time. 3\. The LCMS/MS data of OSCC and control saliva samples will be analyzed to identify potential discriminant variables. Selecting the method, investigator will create dataset, Researcher would like to (i) detect Peaks and (ii) collect markers. The investigators can create dataset display, and at this point, it is also possible to automatically print data into a text file.
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion criteria for case * Age: 18-70 years. * Both genders. * Patient with histo-pathologically diagnosedoral squamous carcinoma * Willing to participate in the study. Inclusion criteria for controls * Healthy patients without any malignancy * Patients relatively almost the same age group of cases Exclusion criteria for cases * Patients with severe periodontitis and multiple carious teeth. * Patients having other systemic diseases and cancer. * Patients who cannot fulfill the inclusion criteria. Exclusion criteria for controls * Having severe periodontal problemsor dental caries * Suffering from any cancer
References
Publications (0)
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