Clinical trial · Interventional
Impact of Exercise and Hyperlipidic Meal on Free Circulating DNA in Patients With Metastatic Colonic Cancer and Healthy Subjects
Impact of Sport Practice and Hyperlipidic Meal on Free Circulating DNA in Patients With Metastatic Colonic Cancer and Healthy Subjects. Physiological Pilot Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The study of circulating tumoral DNA makes it possible to study, without invasive procedures or pathological studies, the tumoral DNA circulating in the blood of a patient and its various alterations. In patients with colon-rectal cancer with resected tumor, circulating tumor DNA can be used as a predictive biomarker of metastatic relapse of cancer. However, the routine extension of circulating tumoral DNA remains limited due to several difficulties. One of the pifalls that circulating tumor DNA is greatly diluted by healthy circulating DNA from non-tumor cells. The amount of healthy circulating DNA has been described as being influenced by certain physiological parameters. The aim of the study is to increase knowledge on the influence of physiological factors associated with sports activity and meal on the release kinetics of circulating DNA.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colon Cancer | Malignant Colon Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Hyperlipidic meal | Other | — | UNRESOLVED |
| Low intensity physical effort | Other | — | UNRESOLVED |
| Measure of circulating DNA | Diagnostic Test | — | UNRESOLVED |
| Moderate intensity physical effort | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Subjects free of malignancy
- description
- Moderate intensity physical effort and meal (once)
- interventionNames
- Other: Moderate intensity physical effort
- Other: Hyperlipidic meal
- Diagnostic Test: Measure of circulating DNA
- type
- EXPERIMENTAL
- label
- Patients with colon cancer
- description
- Low intensity physical effort and meal (visit 1, day of cycle 1 chemotherapy) and low intensity physical effort (visit 2, day of cycle 2 chemotherapy)
- interventionNames
- Other: Low intensity physical effort
- Other: Hyperlipidic meal
- Diagnostic Test: Measure of circulating DNA
Primary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 85 Years
Show eligibility criteria text
Inclusion Criteria: 1. Subjects free of malignancy * men or women 40-70 yrs aged 2. Patients with colon cancer * men or women 18-85 yrs aged * Biopsy-proven colon cancer with indication to chemiotherapy * Chemiotherapy (first line or second line) not started Exclusion Criteria: 1. All subjects * Ischemic cardiac history * known heart disease * blood hemoglobin concentration \<8g / dl * Acute or chronic systemic illnesses, (apart from diabetes, essential or secondary hypertension for patients) * Pregnancy or breastfeeding or in progress 2. Subjects free of malignancy * Cardiovascular risk factor (active smoking or greater than 10 pack-years, diabetes, hypertension or known dyslipidemia not controlled by the diet) * Glomerular filtration rate estimated by the CKD epi (Chronic Kidney Disease - Epidemiology Collaboration) formula \< 60 ml.min-1.1.73 m-² * Contraindication to exercise * Drug taking in progress (except estrogen-progestogen contraception)
References
Publications (0)
Data not yet available