Clinical trial · Interventional
Strategic Intervention on Preserving Language Function During Awake Craniotomy
Strategic Intervention on Preserving Language Function During Awake Craniotomy for Glioma Resection
NCT05143775CI-TRIAL-00055752unknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study is designed to compare the language function after traditional or a new surgical plan during awake craniotomy for glioma resection.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Glioma | Glioma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Awake craniotomy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- new surgical plan group
- description
- The investigators use a monopolar stimulator to determine and retain the tumor margin within 5mm in the sensitive area which is posterior superior longitudinal fasciculus or posterior arcuate fasciculus.
- interventionNames
- Procedure: Awake craniotomy
- type
- ACTIVE_COMPARATOR
- label
- traditional surgical plan group
- description
- The investigators use bipolar stimulator according to the current standard surgery plan. After the positive points are identified, those points would be retained to avoiding language function impairment after the tumor resection.
- interventionNames
- Procedure: Awake craniotomy
Primary outcomes (2)
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: 1, patients with glioma near or on the language function area that have the necessity to undergo awake craniotomy and language function identification during tumor resection Exclusion Criteria: 1. patients with incompleted monitoring procedures; 2. paitents without data of the pre-and postoperative resting state MRI, diffuison tensor image and functional MRI.
References
Publications (2)
- BACKGROUNDFang S, Liang Y, Li L, Wang L, Fan X, Wang Y, Jiang T. Tumor location-based classification of surgery-related language impairments in patients with glioma. J Neurooncol. 2021 Nov;155(2):143-152. doi: 10.1007/s11060-021-03858-9. Epub 2021 Oct 1. PMID 34599481
- DERIVEDLi Y, Weng S, Dong J, Wang J, Zhang Z, Fan X, Wang Y, Ma W, Jiang T, Fang S. Awake Craniotomy for Eloquent Region Glioblastoma Classified by Tumor Location-A Retrospective and Prospective Cohort Study. CNS Neurosci Ther. 2026 Sep;32(9):e71126. doi: 10.1002/cns.71126. PMID 42687123