The Dynamic Process of VMB and Mucosal Immunity After FUS Treatment of CIN Patients With Fertility Requirement

Cervical cancer is the fourth leading cause of cancer death in women worldwide, and cervical intraepithelial neoplasia (CIN) can progress to cervical cancer. Therefore, timely treatment of CIN is critical in preventing the occurrence of cervical cancer. With the implementation and promotion of the World Health Organization's 2030 Global Strategy for the Elimination of Cervical Cancer, an increasing number of women are detecting and treating CIN at an earlier stage. Common treatment methods include ablation treatment and excision treatment, but for women who are planning to have children, the risk of cervical insufficiency and pregnancy complications is greatly increased after excisional treatment, so ablation treatment seems to be a better choice.

Sex

Female

Minimum age

18 Years

Maximum age

60 Years

Inclusion Criteria:

1. patients aged 18-60 years old；
2. patients who had sexual life；
3. patients who had HPV infection;
4. patients who apply to ablation therapy
5. pathological report indicates CIN

Exclusion Criteria:

1. pregnant or lactating women;
2. patients who had cervical treatment ;
3. patients who had genital tract infection ;
4. patients who had chronic diseases, such as allergic diseases ，autoimmune diseases and so on；
5. patients who received antibiotics or pessaries within 14 days of sampling.