Clinical trial · Interventional
Xenon-enhanced Ventilation CT-guided Radiotherapy for Lung Cancer Treatment
Xenon-enhanced Ventilation CT-guided Radiotherapy for Lung Cancer Treatment: Functional Protection of the Lung and Prevention of Radiation Pneumonitis
NCT05134558CI-TRIAL-00055251unknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The investigators aim to use xenon-enhanced ventilation computed tomography (CT) to design personalized functional lung avoidance radiotherapy for lung cancer patients who are scheduled to receive lung radiation therapy. The investigators' goal is to optimally protect the lung function of the patients and reduce the incidence of radiation pneumonitis.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
| Radiation Therapy Complication | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Xenon-enhanced Ventilation CT-guided Radiotherapy | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Xenon-enhanced Ventilation CT-guided Radiotherapy
- description
- Patients will be receiving Xenon-enhanced Ventilation CT-guided Radiotherapy for functional lung avoidance. The doses for the tumors, lungs, and organs at risk will be examined and evaluated.
- interventionNames
- Radiation: Xenon-enhanced Ventilation CT-guided Radiotherapy
Primary outcomes (1)
- measure
- Incidence of radiation pneumonia
- timeFrame
- Within 1 year of radiation therapy
- description
- Incidence of radiation pneumonia
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Patients aged 20-80 years, with lung cancer receiving thoracic radiotherapy in NTUH, from February 2020 to December 2024. Exclusion Criteria: * The age is less than 20 years old or older than 80 years old. * Unstable clinical condition, unable to maintain apnea for 15 second, and history of prior adverse reaction to xenon. * Renal insufficiency patients. * Claustrophobia * Those who are pregnant.
References
Publications (1)
- DERIVEDHuang YS, Chen JL, Ko WC, Lee YF, Chang YC. Computed tomography-based pulmonary vasculature analysis of decreased lung perfusion after thoracic radiotherapy in patients with lung cancer. Int J Radiat Biol. 2025;101(1):35-43. doi: 10.1080/09553002.2024.2435316. Epub 2024 Dec 2. PMID 39621386