Cipterbin Combined With Vinorelbine in the Treatment of HER2-positive MBC

Inclusion Criteria:

* Age ≥18 and ≤70 years old, female.
* BMI index in the range of 19.0\~28.0
* ECOG≤1, and the expected os ≥3 months
* Unresectable metastatic breast cancer diagnosed by histology or pathology that has received one or more chemotherapy regimens.
* HER2 overexpression is +++ by immunohistochemistry (IHC) or + by fluorescence hybridization FISH.
* At least one measurable lesion.
* Sufficient organ function
* Voluntarily signed an informed consent form.
* Subjects with good compliance

Exclusion Criteria:

* Rapid disease progression or threaten important organs and require urgent replacement therapy.
* Undergone surgery within 28 days before treatment (except for biopsy)
* Received radiotherapy within 21 days before the first study drug treatment or the side effects of radiotherapy have not recovered to 0 or 1
* Suffer from other serious uncontrolled diseases (such as epilepsy, liver failure, kidney failure, etc.)
* Suffered from other malignant tumors within 5 years before receiving the first study drug treatment or at the same time.
* Severely infected
* Clear history of mental illness, or have a history of alcoholism or drug abuse.
* Central nervous system metastasis or meningeal metastasis with clinical symptoms
* Cardiac function left ventricular ejection fraction \< 50%
* Obvious arrhythmia, myocardial ischemia, severe atrioventricular block, cardiac insufficiency, severe heart valve Membrane disease patients
* Poorly controlled hypertension
* Patients with coagulopathy: INR or APTT ≥1.5×ULN
* Allergic to the test drug or its excipients in the study treatment, or have a severe allergic reaction to other monoclonal antibody drugs in the past
* Pregnant or breastfeeding, or cannot take reliable contraceptive measures during the trial and within 6 months after the end of the medication Giver
* Have received a certain test drug in other interventional clinical trials, the interval is less than 28 days or less than 5 half lives of the drug (whichever is longer)
* Have used a monoclonal antibody within 6 months before receiving the first study drug treatment
* Have received other drugs that may affect the pharmacokinetic results of the study drug, the interval is less than 28 days or less than 5 half lives of the drug (whichever is longer)
* Have received organ transplants (including autologous/allologous stem cell transplants) in the past
* Other conditions judged by the investigator to be inappropriate for participating in this trial