Clinical trial · Interventional
Chemoradiotherapy Sequenced Radical Surgery for Colorectal Cancer With PALNM
Concurrent Chemoradiotherapy Sequenced Radical Surgery for Para-aortic Lymph Node Metastasis of Left-sided Colon and Rectal Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
In left-sided colon and rectal cancer, the occurrence of synchronous para-aortic lymph node metastasis is rare, with the incidence of being approximate 1-2%. Currently, there has been no standard treatment strategy for this situation. The present trial is designed to evaluate the safety and efficacy of para-aortic lymph node dissection for left-sided colon and rectal cancer with synchronous para-aortic lymph node metastasis
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Chemoradiotherapy | — | UNRESOLVED | — |
| Colorectal Neoplasms Malignant | Colon Neoplasm | PROBABILISTIC | 0.70 |
| Lymph Node Excision | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Radical surgery without PALND | Procedure | — | UNRESOLVED |
| Radical surgery with PALND | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- radical surgery with PALND
- interventionNames
- Procedure: Radical surgery with PALND
- type
- ACTIVE_COMPARATOR
- label
- radical surgery without PALND
- interventionNames
- Procedure: Radical surgery without PALND
Primary outcomes (1)
- measure
- 5-year OS
- timeFrame
- From date of recruitment until the date of death from any cause, assessed up to 5 years
- description
- 5-year overall survival
Secondary outcomes (3)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: * age at enrollment is ≥ 18 and ≤ 75 years * ECOG PS 0-1 * histologically confirmed left-sided colon and rectal carcinoma * synchronous para-aortic lymph node metastases confirmed by PET-CT, and located below the level of renal veins and above the bifurcation of iliac artery * patients potential to receive surgery and achieve no evidence of disease (NED) * able to tolerate surgery * providing written informed consent Exclusion Criteria: * local invasion or distant metastasis other than para-aoritc lymph nodes * history of other malignant tumor * coupled with severe systematic diseases (recent myocardial infarction, cardiomyopathy, or acute pulmonary infection) * emergency surgery
References
Publications (0)
Data not yet available