Clinical trial · Interventional
Propofol EC50 for Inducing Loss of Consciousness in General Combined Epidural Anesthesia
Propofol EC50 for Inducing Loss of Consciousness in Gastrectomy: Combined General and Epidural Anesthesia Versus General Anesthesia
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The beneficial of perioperative usage of thoracic epidural anesthesia and analgesia in various thoracic and upper abdominal surgery are well studied. However, intraoperative data are lacking whether combined thoracic epidural and general anesthesia have effect on the median (50%) effective effect-concentration (EC50) of propofol for inducing loss of consciousness (LOC). We performed this study among patients undergoing open gastrectomy in gastric cancer patients. Sixty patients undergoing open gastrectomy were randomly assigned to two groups with thoracic combined general anesthesia (TEA+GA) or general anesthesia (GA) alone. Target-controlled infusion (TCI) of propofol was used for anesthesia induction. The initial propofol concentration of target effect-site (Ceprop) was 3.5 ug/ml and was increased stepwise by 0.5ug/ml at each 4 min intervals by an un-down sequential method to reach LOC. The predicted Ceprop at the time of LOC, intravenous anesthetics, vasopressor requirement, emergency time from anesthesia and postoperative numeric rating scale (NRS) were recorded and analyzed between two groups.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Gastric Cancer | Malignant Gastric Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| 5-8ml 0.375% ropivacaine | Drug | — | UNRESOLVED |
| 5-8ml normal saline | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Combined epidural with general anesthesia
- description
- Patients in this group received 5-8ml of 0.375% ropivacaine depend on the height and weight of the patient was administrated through the epidural catheter at least 20 min before induction.Followed by a continuous infusion of 4-6 ml 0.375% ropivacaine was applied using micro-infusion pump after induction during surgery.
- interventionNames
- Drug: 5-8ml 0.375% ropivacaine
- type
- SHAM_COMPARATOR
- label
- General anesthesia
- description
- In this group, same dose of normal saline was administered before induction and during surgery.
- interventionNames
- Other: 5-8ml normal saline
Primary outcomes (2)
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: Gastric cancer patients age between 18-75 yrs; ASA physical state I and II Undergoing open gastrectomy Exclusion Criteria: With contraindications to epidural puncture or catheter placement Chronic or acute (within 48 h) intake of psychotropic drugs, benzodiazepines, anticonvulsants, or opioids; alcoholism Hepatic, renal, neurological or other organ dysfunctiony Younger than 18 years or older than 75 years Allergic to local anesthetic solutions or opioids Received neo-adjuvant chemotherapy Refuse to receive epidural puncture
References
Publications (1)
- DERIVEDWang J, Shen Y, Guo W, Zhang W, Cui X, Cai S, Chen X. Propofol EC50 for inducing loss of consciousness in patients under combined epidural-general anesthesia or general anesthesia alone: a randomized double-blind study. Front Med (Lausanne). 2023 Nov 6;10:1194077. doi: 10.3389/fmed.2023.1194077. eCollection 2023. PMID 38020175