Clinical trial · Interventional
Recurrences After Standard EMR vs Plus Thermal Ablation EMR
Recurrences After Standard EMR vs Plus Thermal Ablation EMR of Advanced Sessile and Lateral Spreading Colorectal Adenoma
NCT05121805CI-TRIAL-00072534RESPECTunknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The primary objective of this trial is to investigate whether thermal ablation EMR with soft tip snare coagulation (STSC) reduces the recurrence rate of lateral spreading or sessile polyps ≥20mm compared to standard EMR.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Polyps of Colon | — | UNRESOLVED | — |
| Recurrence, Local Neoplasm | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Snare tip soft coagulation | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- EMR plus snare tip soft coagulation
- description
- Post procedural prophylactic coagulation of the entire margin of the resection site creating a 2-3mm rim.
- interventionNames
- Procedure: Snare tip soft coagulation
- type
- NO_INTERVENTION
- label
- Standard EMR
- description
- No prophylactic coagulation
Primary outcomes (1)
- measure
- Recurrence
- timeFrame
- 6 months
- description
- Adenoma recurrence at resection site
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Proven colorectal sessile or lateral spreading polyps with a diameter of ≥ 20mm requiring piecemeal resection with EMR. Exclusion Criteria: * Previously attempted intervention * Polyps with any signs of invasive malignancy * Presence or suspicion of inflammatory bowel disease * En bloc resection * Incomplete resection
References
Publications (1)
- DERIVEDKemper G, Gerges C, Schoon EJ, Schreuder RM, Schrauwen RRW, Epping LSM, Beyna T, Drenth JPH, Gundug U, Siersema PD, van Geenen EJM; ENDOCARE study group. Recurrences of advanced sessile and lateral spreading colorectal adenoma after endoscopic mucosal resection (EMR) thermal ablation versus no adjuvant therapy (RESPECT): a protocol of an international randomized controlled trial. Trials. 2024 Feb 17;25(1):132. doi: 10.1186/s13063-024-07915-2. PMID 38368409