Clinical trial · Interventional
The Impact of Resistance ExerciSe on Muscle Mass in GlioblaSToma Survivors
The Impact of Resistance ExerciSe on Muscle Mass in GlioblaSToma Survivors (RESIST)
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Glioblastoma patients are confronted with a debilitating disease associated with a low survival rate and poor quality of life. The goal of this study will be to reach a largely underrepresented population in the exercise literature and explore the role of a tailored circuit-based resistance training program on functional fitness (i.e., ability to carry out tasks of daily living) and associated health outcomes (e.g., quality of life) for GBM patients on active treatment.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Brain Cancer | Malignant Brain Neoplasm | ALIAS | 0.90 |
| Glioblastoma Multiforme of Brain | Brain Glioblastoma | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Circuit-based resistance exercise (CRT) | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Exercise Intervention
- description
- 12-week circuit-based resistance exercise
- interventionNames
- Behavioral: Circuit-based resistance exercise (CRT)
- type
- NO_INTERVENTION
- label
- Wait-list Control
- description
- Standard of care wait-list control group
Primary outcomes (2)
- measure
- Functional Performance
- timeFrame
- Baseline to post-intervention (12-week) change
- description
- Short Physical Performance Battery to assess activities of daily living
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * histologically confirmed diagnosis of either primary or secondary GBM * received any dose of DEX * Karnofsky Performance Status (KPS) \>70 * English fluency * physician approval * willingness to travel to Halifax to participate. Exclusion Criteria: * unstable or symptomatic cardiac or pulmonary disease, injury or co-morbid disease that precludes ability to safely exercise * significant cognitive limitations * uncontrolled seizures associated with impaired awareness
References
Publications (1)
- DERIVEDKeats MR, Grandy SA, Blanchard C, Fowles JR, Neyedli HF, Weeks AC, MacNeil MV. The Impact of Resistance Exercise on Muscle Mass in Glioblastoma in Survivors (RESIST): Protocol for a Randomized Controlled Trial. JMIR Res Protoc. 2022 May 4;11(5):e37709. doi: 10.2196/37709. PMID 35507403