Clinical trial · Interventional
Endobronchial Ultrasound Needle Aspiration With and Without Suction
Diagnostic Accuracy of Endobronchial Ultrasound Needle Aspiration With and Without Suction: a Single-center Randomized Controlled Trial
NCT05110950CI-TRIAL-00058726unknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The main purpose of the present study is to compare the diagnostic yield of different aspiration techniques in Ultrasound-guided Transbronchial Needle Aspiration (EBUS-TBNA) in the diagnosis of hilar/mediastinal adenopathy
Conditions
Conditions (10)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| ALK Translocation | — | UNRESOLVED | — |
| EGF-R Positive Non-Small Cell Lung Cancer | — | UNRESOLVED | — |
| Hilar Lymphadenopathy | — | UNRESOLVED | — |
| Lung Neoplasms | Lung Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Lymphoma | Lymphoma | ONTOLOGY_EXACT | 0.90 |
| Mediastinal Lymphadenopathy | — | UNRESOLVED | — |
| PDL1 Gene Mutation | — | UNRESOLVED | — |
| ROS1 Gene Mutation | — | UNRESOLVED | — |
| Sarcoidosis | — | UNRESOLVED | — |
| Tuberculosis | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Manual applied suction EBUS-TBNA through a pistol-grip syringe holder | Procedure | — | UNRESOLVED |
| No suction EBUS-TBNA | Procedure | — | UNRESOLVED |
| Passive suction through dedicated EBUS-TBNA syringe | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- ACTIVE_COMPARATOR
- label
- No suction EBUS-TBNA
- description
- In this technique the stylet is slowly removed without any kind of device in order to avoid active suction.
- interventionNames
- Procedure: No suction EBUS-TBNA
- type
- ACTIVE_COMPARATOR
- label
- Passive suction through dedicated EBUS-TBNA syringe
- description
- After rapid stylet removal, suction is applied through a vacuteiner syringe, without active aspiration.
- interventionNames
- Procedure: Passive suction through dedicated EBUS-TBNA syringe
- type
- ACTIVE_COMPARATOR
- label
- Manual applied suction EBUS-TBNA through a pistol-grip syringe holder
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * age ≥ 18years; * presence of at least one hilar/mediastinal adenopathy \>1 cm on short axis assessed by contrast-enhanced CT scan and/or hypermetabolic adenopathy assessed by FDG-PET; * ability to give an informed consent Exclusion Criteria: * coagulopathy or bleeding diathesis that cannot be corrected; * severe refractory hypoxemia; * unstable hemodynamic status; * inability to give an informed consent
References
Publications (4)
- RESULTLabarca G, Folch E, Jantz M, Mehta HJ, Majid A, Fernandez-Bussy S. Adequacy of Samples Obtained by Endobronchial Ultrasound with Transbronchial Needle Aspiration for Molecular Analysis in Patients with Non-Small Cell Lung Cancer. Systematic Review and Meta-Analysis. Ann Am Thorac Soc. 2018 Oct;15(10):1205-1216. doi: 10.1513/AnnalsATS.201801-045OC. PMID 30011388
- RESULTWahidi MM, Herth F, Yasufuku K, Shepherd RW, Yarmus L, Chawla M, Lamb C, Casey KR, Patel S, Silvestri GA, Feller-Kopman DJ. Technical Aspects of Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration: CHEST Guideline and Expert Panel Report. Chest. 2016 Mar;149(3):816-35. doi: 10.1378/chest.15-1216. Epub 2016 Jan 12. PMID 26402427
- RESULTHe X, Wu Y, Wang H, Yu G, Xu B, Jia N, Yao Z. Slow-pull capillary technique versus suction technique in endobronchial ultrasound-guided transbronchial needle aspiration for diagnosing diseases involving hilar and mediastinal lymph node enlargement. Ther Adv Respir Dis. 2020 Jan-Dec;14:1753466620907037. doi: 10.1177/1753466620907037. PMID 32103709
- RESULTLin X, Ye M, Li Y, Ren J, Lou Q, Li Y, Jin X, Wang KP, Chen C. Randomized controlled trial to evaluate the utility of suction and inner-stylet of EBUS-TBNA for mediastinal and hilar lymphadenopathy. BMC Pulm Med. 2018 Dec 7;18(1):192. doi: 10.1186/s12890-018-0751-0. PMID 30526587