Clinical trial · Observational
Single-centre Propensity Score-matched Comparison of Laparoscopic Versus Open Pancreatoduodenectomy
Morbidity and Survival After Minimally Invasive Versus Open Pancreatoduodenectomy: Propensity Score Matched Comparison
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Minimally invasive pancreatoduodenectomy is increasingly performed. However, technical challenges and a perceived higher risk of complications has hindered wide adoption of a minimally invasive approach. This is a retrospective comparison of a prospectively kept database. The investigators compared surgical outcomes and survival after laparoscopic (LPD) versus open pancreatoduodenectomy (OPD). In order to reduce the effect of bias and confounding, baseline characteristics of both groups were matched using propensity score matching.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pancreatic Neoplasms | Pancreatic Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| pancreatoduodenectomy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Laparoscopic pancreatoduodenectomy
- description
- Cohort of patients that underwent a Whipple-procedure through a laparoscopic approach.
- interventionNames
- Procedure: pancreatoduodenectomy
- label
- Open pancreatoduodenectomy
- description
- Cohort of patients that underwent a Whipple-procedure through a traditional open approach.
- interventionNames
- Procedure: pancreatoduodenectomy
Primary outcomes (1)
- measure
- Major complication rate
- timeFrame
- 90 days postoperative
- description
- Complications classified as morbidity classification 3a or greater (Clavien-Dindo)
Secondary outcomes (6)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * diagnosis of lesion of pancreatic head or peri-ampullary organs Exclusion Criteria: * \< 18 years old
References
Publications (1)
- DERIVEDVandeputte M, Vansteenkiste F, Ceelen W, De Meyere C, D'Hondt M. Morbidity and survival after laparoscopic versus open pancreatoduodenectomy: propensity score matched comparison. Langenbecks Arch Surg. 2023 Jan 10;408(1):16. doi: 10.1007/s00423-023-02758-y. PMID 36624235