Clinical trial · Interventional
Effect of Rectal Misoprostol in Reducing Intra-operative Blood Loss During Myomectomy
Effect of Rectal Misoprostol in Reducing Intra-operative Blood Loss During Myomectomy A Randomized Control Trial
NCT05108597CI-TRIAL-00054899completedPhase 3ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
A total of 200 women for elective abdominal myomectomy were randomly allocated into two groups. 100 women in experimental group were administered 400ug Misoprostol (2 tablets of Prosotec®) through the rectal route prior to surgery and 100 were in control group, in which no drug was administered.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Blood Loss, Surgical | — | UNRESOLVED | — |
| Uterine Myoma | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Misoprostol | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Misoprostol (Study Group)
- description
- In study group, 400ug misoprostol will be administered through rectal route, 1 hour before surgery.
- interventionNames
- Drug: Misoprostol
- type
- NO_INTERVENTION
- label
- No drug
- description
- In control group no dose will be administered
Primary outcomes (1)
- measure
- Intraoperative blood loss
- timeFrame
- During the surgical procedure
- description
- Intraoperative blood loss will be recorded by a trained doctor and calculated using visual scale for the abdominal sponges and chest swabs/gauzes used during surgery and blood collected in suction bottle.
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 50 Years
Show eligibility criteria text
Inclusion Criteria: 1. ASA physical status class I-II 2. Intramural or subserosal fibroids - diagnosed on ultrasound 3. Candidates for elective abdominal myomectomy Exclusion Criteria: 1. Pre-operative Hemoglobin \< 10 g/dl 2. Patient who received Danazol or GnRH analogues before surgery 3. No other systemic or metabolic disease
References
Publications (0)
Data not yet available
No reference posted for this study.