Clinical trial · Observational
Mutation Detection for VRL
The Diagnostic Value of Mutation Detection for VRL
NCT05102994CI-TRIAL-00055027unknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Vitreoretinal lymphoma (VRL) is a rare but aggressive masquerade syndrome, which would be easily confused with uveitis. The diagnostic gold standard remains the pathologic examination of ocular specimen with invasiveness and low sensitivity. To improve the safety and accuracy of VRL diagnosis, alternative techniques using intraocular fluid (IOF) samples are emerging. In this study, we aimed to test the diagnostic value of mutation analysis for VRL
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Uveitis | — | UNRESOLVED | — |
| Vitreoretinal Lymphoma | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| mutation test | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- VRL patients group
- description
- Presenting clinical features suggestive for VRL with positive finding in laboratory exam
- interventionNames
- Diagnostic Test: mutation test
- label
- uveitis group
- description
- Even if characterized as clinical features of presumed VRL, no positive laboratory investigations for lymphoma and well response to IMT
- interventionNames
- Diagnostic Test: mutation test
Primary outcomes (1)
- measure
- the result of mutation test
- timeFrame
- at baseline, before treatment
- description
- any mutation detect in intraocular fluild recorded as ctDNA+
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: * suspected VRL patients who had intraocular fluid for mutation test. And got a clear diagnose of VRL or uveitis afther having dianostic tests and follow-up treatment Exclusion Criteria: * suspected VRL patients who lost in follow-up without a definitive diagnose, or whoever reluctance to participate our study
References
Publications (0)
Data not yet available
No reference posted for this study.