Clinical trial · Observational
Cognition and QoL After Thyroid Surgery
Longitudinal Evaluation of Objective Cognitive Function and Quality of Life in Patients Undergoing Surgery for Malignant and Benign Thyroid Nodules
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The development of cognitive dysfunction can profoundly affect HR-QoL as well as the possibility of societal participation and ability to work, and thereby relevantly impacts prospects for cancer survivorship. The aim of the study is to obtain improved understanding of the scope and magnitude of objective cognitive dysfunction in DTC survivors, and its relation to subjective cognitive dysfunction, thyroid hormone levels, physical activity and HRQoL. This is done in a prospective study where patients operated for a thyroid nodule (Bethesda IV-VI, i.e., benign \[goitre with nodule and fibroadenomas\], low-risk DTC and intermediate-high risk DTC) are included and asked to serially perform online neuropsychological testing as well as to complete questionnaires related to HR-QoL, physical activity and additional psychological and physical complaints. Blood is analysed for levels of thyroid hormones and systemic inflammation.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cognitive Decline | — | UNRESOLVED | — |
| Survivorship | — | UNRESOLVED | — |
| Symptoms, Cognitive | — | UNRESOLVED | — |
| Thyroid Cancer | Malignant Thyroid Gland Neoplasm | CURATED_EXACT | 0.92 |
| Thyroid Nodule | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Objective cognitive functioning by means of an online neuropsychological test (Amsterdam Cognition Scale, ACS)
- timeFrame
- pre-surgery to 12 months post-surgery
- description
- change in total score on ACS
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Age \>18 years old, indication for surgery because of a thyroid nodule Bethesda IV-VI * Able to read and understand the Swedish language * Access to desktop computer or laptop with internet connection * Able and willing to provide written informed consent Exclusion Criteria: * A previous diagnosis of (auto-immune) hypothyroidism * A previous cancer diagnosis (excluding basal cell cancer of the skin) * Indications for surgery other than (solely) a thyroid nodule (i.e., concomitant Graves) * A diagnosis of medullary and anaplastic thyroid cancer
References
Publications (0)
Data not yet available