Clinical trial · Interventional
A Comparative Study Between Regional Anesthesia in Thoracoscopes and the Conventional General Anesthesia
A Comparative Study Between Thoracic Epidural Anesthesia in Non-Intubated Video-Assisted Thoracoscopes and the Conventional General Anesthesia With One Lung Ventilation
NCT05077111CI-TRIAL-00054460VATSunknownPhase 4ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Video-assisted thoracic surgery (VATS) is usually performed with general anesthesia and single lung ventilation. However, performing thoracic surgery under awake regional anesthesia has several potential advantages including avoidance of airway trauma and ventilator dependence associated with endotracheal intubation, besides promoting enhanced recovery after surgery and shorter mean hospital stay.
Conditions
Conditions (12)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hemothorax | — | UNRESOLVED | — |
| Mediastinal Lymphadenopathy | — | UNRESOLVED | — |
| Pericardial Effusion | — | UNRESOLVED | — |
| Pleural Diseases | — | UNRESOLVED | — |
| Pleural Effusion, Malignant | — | UNRESOLVED | — |
| Pleural Empyema | — | UNRESOLVED | — |
| Pleural Mesothelioma | Pleural Mesothelial Neoplasm | ALIAS | 0.90 |
| Pleural Neoplasms | Pleural Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Pneumothorax and Air Leak | — | UNRESOLVED | — |
| Pulmonary Atelectasis | — | UNRESOLVED | — |
| Pulmonary Diseases or Conditions |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| General Anesthesia with One Lung Ventilation | Procedure | — | UNRESOLVED |
| Thoracic Epidural Anesthesia | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Group A
- description
- sole Thoracic Epidural Anesthesia
- interventionNames
- Procedure: Thoracic Epidural Anesthesia
- type
- ACTIVE_COMPARATOR
- label
- Group B
- description
- General Anesthesia with One Lung Ventilation
- interventionNames
- Procedure: General Anesthesia with One Lung Ventilation
Primary outcomes (1)
- measure
- Perioperative changes in blood gases
- timeFrame
- Imediately before operation, intraoperatively per hour, and postoperatively till 24 hours
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 21 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * ASA less than or equal II. * The procedure expected to be completed within 2 hours. Exclusion Criteria: * Patients with expected difficult airway management. * Hemodynamically unstable patients. * Persistent cough or high airway secretions. * Severe Emphysema or clinical signs of active infectious disease. * Hypoxemia (PaO2 \<60 mmHg) or hypercarbia (PCO2 \>50 mmHg) * Coagulopathy (INR \>1.5). * Obesity (BMI \>30 Kg/m 2 ). * Infection at the injection site, allergy to local anesthetics. * Neurological disorders: seizures, intracranial mass or brain edema.
References
Publications (4)
- BACKGROUNDChen KC, Cheng YJ, Hung MH, Tseng YD, Chen JS. Nonintubated thoracoscopic lung resection: a 3-year experience with 285 cases in a single institution. J Thorac Dis. 2012 Aug;4(4):347-51. doi: 10.3978/j.issn.2072-1439.2012.08.07. PMID 22934136
- BACKGROUNDDeng HY, Zhu ZJ, Wang YC, Wang WP, Ni PZ, Chen LQ. Non-intubated video-assisted thoracoscopic surgery under loco-regional anaesthesia for thoracic surgery: a meta-analysis. Interact Cardiovasc Thorac Surg. 2016 Jul;23(1):31-40. doi: 10.1093/icvts/ivw055. Epub 2016 Mar 16. PMID 26984963
- BACKGROUNDPompeo E, Mineo D, Rogliani P, Sabato AF, Mineo TC. Feasibility and results of awake thoracoscopic resection of solitary pulmonary nodules. Ann Thorac Surg. 2004 Nov;78(5):1761-8. doi: 10.1016/j.athoracsur.2004.05.083. PMID 15511470
- BACKGROUNDPompeo E, Sorge R, Akopov A, Congregado M, Grodzki T; ESTS Non-intubated Thoracic Surgery Working Group. Non-intubated thoracic surgery-A survey from the European Society of Thoracic Surgeons. Ann Transl Med. 2015 Mar;3(3):37. doi: 10.3978/j.issn.2305-5839.2015.01.34. PMID 25815298