Clinical trial · Observational
Prognostic Values of Inflammation-based Indices in Gastric Cancer
Comparison of the Prognostic Values of Preoperative Inflammation-based Indices in Patients Undergoing Resection of Gastric Cancer
NCT05075421CI-TRIAL-00057228completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study aims to evaluate the prognostic values of preoperative inflammation-based indices in patients undergoing potentially curative resection of gastric cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Gastric Cancer | Malignant Gastric Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Gastrectomy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Group 1 (high marker)
- description
- Patients with elevated serum markers
- interventionNames
- Procedure: Gastrectomy
- label
- Group 2 (normal marker)
- description
- Patients with normal value of serum markers
- interventionNames
- Procedure: Gastrectomy
Primary outcomes (1)
- measure
- 5-year survival rates
- timeFrame
- 5 years
- description
- The primary clinical outcome of interest is 5-year survival rates.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients over the age of 18 who underwent a surgical procedure for gastric cancer Exclusion Criteria: * Patients \< 18 years of age * Patients with no routine blood examination before surgery or incomplete medical records * Patients followed up less than 3 months * Patients with additional malignancy * Patients having tumors that invading adjacent organs * Patients with adjacent or distant metastasis * Patients receiving neoadjuvant therapy (chemo- or radiotherapy) * Patients with previous malignancy history * Patients with a clinical evidence of infection * Patients with a history of preoperative use of anti-inflammatory drugs or immunosuppressive treatment * Patients with a history of chronic inflammatory disease or autoimmune disease * Patients who underwent emergency surgical resection * Patients who have undergone R1/R2 resection or those with positive peripheral margins * Patients with missing data on follow-up
References
Publications (5)
- BACKGROUNDWen J, Bedford M, Begum R, Mitchell H, Hodson J, Whiting J, Griffiths E. The value of inflammation based prognostic scores in patients undergoing surgical resection for oesophageal and gastric carcinoma. J Surg Oncol. 2018 Jun;117(8):1697-1707. doi: 10.1002/jso.25057. Epub 2018 May 14. PMID 29761518
- BACKGROUNDCrumley AB, McMillan DC, McKernan M, McDonald AC, Stuart RC. Evaluation of an inflammation-based prognostic score in patients with inoperable gastro-oesophageal cancer. Br J Cancer. 2006 Mar 13;94(5):637-41. doi: 10.1038/sj.bjc.6602998. PMID 16479253
- BACKGROUNDCrumley AB, McMillan DC, McKernan M, Going JJ, Shearer CJ, Stuart RC. An elevated C-reactive protein concentration, prior to surgery, predicts poor cancer-specific survival in patients undergoing resection for gastro-oesophageal cancer. Br J Cancer. 2006 Jun 5;94(11):1568-71. doi: 10.1038/sj.bjc.6603150. PMID 16685271
- BACKGROUNDCrumley AB, Stuart RC, McKernan M, Going JJ, Shearer CJ, McMillan DC. Comparison of pre-treatment clinical prognostic factors in patients with gastro-oesophageal cancer and proposal of a new staging system. J Gastrointest Surg. 2010 May;14(5):781-7. doi: 10.1007/s11605-010-1162-6. Epub 2010 Feb 11. PMID 20148314
- BACKGROUNDDutta S, Crumley AB, Fullarton GM, Horgan PG, McMillan DC. Comparison of the prognostic value of tumour and patient related factors in patients undergoing potentially curative resection of gastric cancer. Am J Surg. 2012 Sep;204(3):294-9. doi: 10.1016/j.amjsurg.2011.10.015. Epub 2012 Mar 22. PMID 22444831