Clinical trial · Observational
A Review of Functional and Surgical Outcomes of Gynaecological Reconstruction in the Context of Pelvic Exenteration
PelvEx 7: A Review of Functional and Surgical Outcomes of Gynaecological Reconstruction in the Context of Pelvic Exenteration
NCT05074069CI-TRIAL-00065231completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Patients with locally advanced pelvic malignancy undergo radical procedures, necessitate organ reconstruction. Little is known about the preferred methods of gynaecological organ reconstruction in the context of pelvic exenteration. This review aims to identify which methods are commonly used and what outcomes are associated with each technique in order to further guide future practice.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pelvic Cancer | Malignant Pelvic Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Gynaecological reconstruction | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- label
- Neovaginal reconstruction
- description
- Neovaginal reconstruction post-vulvovaginal resection
- interventionNames
- Procedure: Gynaecological reconstruction
- label
- Flap Reconstruction
- description
- Flap closure of perineal defect post-gynaecological organ resection
- interventionNames
- Procedure: Gynaecological reconstruction
- label
- No reconstruction/Primary closure
- description
- Primary closure of defect post-multivisceral, gynaecological organ-involving, resection
Primary outcomes (3)
- measure
- Morbidity
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Histologically proven locally advanced or recurrent pelvic cancer (all subtypes - Rectal, Urological, Gynae, Sarcome) * Aged over 18 years * Undergoing a multi-visceral extended pelvic resection and requiring gynaecological reconstruction at the time of index operation * Time period: 1st July 2016 - 31st July 2021 Exclusion Criteria: * Strong evidence of metastatic or peritoneal disease * No histological evidence of gynaecological organ involvement * Procedure not carried out with curative intent * Insufficient patient follow-up (Minimum of 30 days)
References
Publications (1)
- DERIVEDPelvEx Collaborative. A review of functional and surgical outcomes of gynaecological reconstruction in the context of pelvic exenteration. Surg Oncol. 2024 Feb;52:101996. doi: 10.1016/j.suronc.2023.101996. Epub 2023 Nov 22. PMID 38096764