Clinical trial · Interventional
Evaluation for Benign and Malignant Pulmonary Ground-glass Nodules Based on MRI Dynamic Contrast Enhanced Imaging
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Computed tomography (CT) is critical for the diagnosis of lung nodules as well as for therapeutic management. Repeated CT examinations will raise the issue of the cumulative radiation dose and subsequent risk of cancer, thus pushing the need for imaging techniques using low or no radiation dose. Magnetic Resonance Imagery (MRI) with ultrashort echo time (UTE) pulse sequences with high signal-to-noise and spatial resolution is a promising alternative for lung nodules imaging.The purpose of the study is to evaluate the value of dynamic contrast-enhanced MR imaging (DCE-MRI) to discriminate of malignant from benign lesions.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pulmonary Nodules | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| MRI scan | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- MRI scan
- description
- All participants will undergo 1 DCE-MRI scan before surgery or puncture.
- interventionNames
- Diagnostic Test: MRI scan
Primary outcomes (3)
- measure
- Volume transfer constant (Ktrans)
- timeFrame
- 12 months
- description
- Pharmacokinetic parameters will be estimated by fitting a pharmacokinetic model to the actual time-intensity curves obtained from the DCE-MRI.
- measure
- the fractional volume of extravascular extracellular space of the target tissue (ve)
- timeFrame
- 12 months
- description
- Pharmacokinetic parameters will be estimated by fitting a pharmacokinetic model to the actual time-intensity curves obtained from the DCE-MRI.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Ground-glass pulmonary nodules found by CT scan * Plan to accept surgery or puncture due to the pulmonary nodules * Absence of treatment such as chemotherapy or radiotherapy and biopsy * Adequate renal function to tolerate intravenous gadolinium * Agree to sign informed consent * Able to lie still during DCE-MRI Exclusion Criteria: * Fail to understand or agree to sign informed consent * Implanted pacemaker or cardiac defibrillator * Contraindications to undergoing MRI * Uncontrolled intercurrent illness * Pregnant or breastfeeding
References
Publications (0)
Data not yet available