Clinical trial · Observational
Extramedullary Acute Myeloid Leukemia (eAML): Retrospective Single Center Cohort Study, Clinicopathological, Molecular Analysis and Survival Outcomes
NCT05057299CI-TRIAL-00054087completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Patients with extramedullary leukemia were identified over 10 years (January 2003 to September 2019). Clinicopathological,genetic-molecular features were identified and survival outcomes were studied and analyzed.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Acute Myeloid Leukemia | Acute Myeloid Leukemia | CURATED_BROADER | 0.80 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| retrospective data analysis | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Patients with extramedullary leukemia(eAML) with myeloid neoplasms
- interventionNames
- Other: retrospective data analysis
Primary outcomes (1)
- measure
- Overall survival (OS),
- timeFrame
- "4 year, year 4"
- description
- To calculate the median and estimated 4-year overall survival
Secondary outcomes (1)
- measure
- Progression-Free Survival
- timeFrame
- "4 year, year 4"
- description
- To calculate the median and estimated 4-year PFS
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Adult subjects aged ≥18 year and up to 75 years * Male and females. * Initially diagnosed and treated with extramedullary leukemia at KHCC and followed till last encounter. * Patients, who underwent an allogeneic stem cell transplant. * Period January 2003-September 2019 Exclusion Criteria: * Pediatric patients \<18 year of age * Patients, who lost their follow up within study period.
References
Publications (2)
- BACKGROUNDShallis RM, Wang R, Davidoff A, Ma X, Zeidan AM. Epidemiology of acute myeloid leukemia: Recent progress and enduring challenges. Blood Rev. 2019 Jul;36:70-87. doi: 10.1016/j.blre.2019.04.005. Epub 2019 Apr 29. PMID 31101526
- RESULTShallis RM, Gale RP, Lazarus HM, Roberts KB, Xu ML, Seropian SE, Gore SD, Podoltsev NA. Myeloid sarcoma, chloroma, or extramedullary acute myeloid leukemia tumor: A tale of misnomers, controversy and the unresolved. Blood Rev. 2021 May;47:100773. doi: 10.1016/j.blre.2020.100773. Epub 2020 Oct 30. PMID 33213985