Clinical trial · Interventional
An Investigational Scan (MRI With Dixon Based Sequences) in Detecting Prostate Cancer
Evaluation of MRI With Dixon Based Sequences in the Detection of Prostate Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This trial studies the use of magnetic resonance imaging (MRI) with Dixon based imaging sequences in detecting prostate cancer. MRI uses radio waves and a powerful magnet linked to a computer to create detailed pictures of areas inside the body. Researchers hope to learn if using a modified MRI scan technique with Dixon based imaging sequencing will help to produce better images of prostate cancer than the standard of care MRI scan technique.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Prostate Carcinoma | Prostate Carcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Dixon MRI | Procedure | — | UNRESOLVED |
| Magnetic Resonance Imaging | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Diagnostic (standard MRI, Dixon MRI)
- description
- Patients undergo MRI with additional Dixon based sequences with fat and water over a total of 49 minutes.
- interventionNames
- Procedure: Dixon MRI
- Procedure: Magnetic Resonance Imaging
Primary outcomes (1)
- measure
- Detection of at least one or more prostate lesions with Dixon sequencing
- timeFrame
- through study completion, an average of 1 year
- description
- Will evaluate and compare the accuracy of Dixon based sequencing to the conventional T2 weighted sequencing for detection of intraprostatic tumor and extraprostatic tumor extension. Lesions will be within any of six regions of the prostate: left apex, left mid, left base, right apex, right mid, and right base. The relative sensitivity and specificity of the two sequencing methods will be compared using an adjusted McNemar's test for clustered data where clusters consist of the matched pairs of within patient-zone observations. The primary analysis will also provide 95% confidence intervals for marginal sensitivity and specificity using a generalized linear mixed model.
Eligibility
Eligibility (as posted)
- Sex
- Male
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Biopsy proven prostate cancer patients who are scheduled to undergo prostatectomy. * Patient who is scheduled to have a clinically indicated staging endorectal prostate MRI exam. * Patients who have signed their informed consent form to undergo the study. Exclusion Criteria: * Known prior hormone ablation or radiation therapy (pelvic or prostate). * Patients who do not want to undergo prostatectomy and prefer other therapy or surveillance. * Contraindication to conventional MR imaging (e. g. metal implants, pace maker, etc.).
References
Publications (0)
Data not yet available