Clinical trial · Interventional
EXPAREL or Lidocane as Local Anesthetic in Patients Undergoing Pleuroscopy With Pleural Biopsy and Indwelling Pleural Catheter Placement
A Randomized Blinded Controlled Trial of EXPAREL vs 1% Lidocane as Local Anesthetic in Patients Undergoing Pleuroscopy With Pleural Biopsy and Indwelling Pleural Catheter Placement
NCT05044468CI-TRIAL-00104996active not recruitingPhase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This phase II trial investigates the effect of EXPAREL compared to lidocane as a local anesthetic in patients who are undergoing pleuroscopy with pleural biopsy and indwelling pleural catheter placement. This trial aims to see whether EXPAREL or lidocane is able to make patients more comfortable.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Malignant Pleural Neoplasm | Malignant Pleural Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Lidocaine | Drug | — | UNRESOLVED |
| Liposomal Bupivacaine | Drug | — | UNRESOLVED |
| Questionnaire Administration | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Group A (liposomal bupivacaine)
- description
- Patients receive liposomal bupivacaine via injection into the intercostal nerve block.
- interventionNames
- Drug: Liposomal Bupivacaine
- Other: Questionnaire Administration
- type
- ACTIVE_COMPARATOR
- label
- Group B (lidocaine)
- description
- Patients receive lidocaine via injection into the pleuroscopy port incision sites and indwelling pleural catheter site.
- interventionNames
- Drug: Lidocaine
- Other: Questionnaire Administration
Primary outcomes (1)
- measure
- Global chest pain score
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion criteria: 1. Referral to pulmonary services for pleuroscopy with biopsies and IPC placement/chest tube placement 2. Age \> 18 Exclusion criteria: 1. Inability to provide informed consent 2. Study subject has any disease or condition that interferes with safe completion of the study including: a. Allergic reaction to EXPAREL 3. Need for pleurodesis 4. Allergies to lidocaine or other local anesthetics. 5. Pregnancy 6. Advanced liver disease where the clinician deems the procedure unsafe
References
Publications (0)
Data not yet available
No reference posted for this study.