Clinical trial · Interventional
Cold Snare Endoscopic Mucosal Resection (EMR) vs Cold EMR With Margin Snare Tip Soft Coagulation (STSC)
Cold Snare Endoscopic Mucosal Resection vs Cold Snare Endoscopic Mucosal Resection With Adjuvant Thermal Therapy to Resection Margins - A Randomised Controlled Trial
NCT05041478CI-TRIAL-00087740recruitingN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Randomised controlled trial comparing cold snare endoscopic mucosal resection (EMR) with cold snare EMR and adjuvant margin STSC in the complete resection of 15-40mm lateral-spreading adenomas
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colon Adenoma | Colon Adenoma | ONTOLOGY_EXACT | 0.98 |
| Colon Cancer | Malignant Colon Neoplasm | CURATED_EXACT | 0.92 |
| Colorectal Polyp | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Cold Snare Endoscopic Mucosal Resection | Procedure | — | UNRESOLVED |
| Cold Snare Endoscopic mucosal resection with adjuvant snare tip soft coagulation | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Cold EMR with adjuvant STSC to margins
- description
- Standard cold EMR technique with adjuvant snare tip soft coagulation to defect margins
- interventionNames
- Procedure: Cold Snare Endoscopic mucosal resection with adjuvant snare tip soft coagulation
- type
- ACTIVE_COMPARATOR
- label
- Cold EMR
- description
- Standard Cold EMR resection technique
- interventionNames
- Procedure: Cold Snare Endoscopic Mucosal Resection
Primary outcomes (2)
- measure
- Complete resection rate (CRR)
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Any patient undergoing colonoscopy who is older than 18 years of age, has a written consent for trial participation and has at least one laterally spreading lesion meeting the following description: * Localisation in the colon or rectum * Benign adenomatous surface features (Kudo III / IV, Japan NBI Expert Team (JNET) 2a) * Granular or non-granular topography * Paris classification 0-IIa/IIb +/- Is * If present, sessile component may be no greater than 10mm in size. * Polyp size ranging from 15 to 40mm Exclusion Criteria: * Current use of antiplatelet (excluding aspirin) or anticoagulants which have not appropriately been interrupted according to the guidelines. * Known bleeding disorder or coagulopathy. * Pregnancy * History of inflammatory bowel disease * Previously attempted or otherwise non-lifting lesions * Endoscopic features suggestive of submucosal invasion (Kudo Vi/n, JNET 2b / 3) or concurrent colorectal cancer * Lesions involving the ileocaecal valve (ICV), appendiceal oriface or anorectal junction (ARJ)
References
Publications (0)
Data not yet available
No reference posted for this study.