A Study to Evaluate Efficacy and Safety of TheraSphere and Resection Combination Therapy in Patients With Single Large ((> 5cm, Long Diameter ) Hepatocellular Carcinoma : Exploratory Trial

Inclusion Criteria:

1. Signed written informed consent
2. Clinical or histological diagnosis of HCC based on the guidelines of the American Association for the Study of Liver Diseases (AASLD).
3. Single large (\> 5cm, long diameter) lesion that is typically enhanced\* and bi-dimensionally measurable by multiphasic spiral CT scan and dynamic contrast-enhanced MRI.
4. Tumor conditions confirmed by abdominal imaging (contrast enhanced CT ± MRI) performed within 28 days prior to the enrollment
5. Age of at least 19 years.
6. ECOG Performance Status of 0.
7. Child-Pugh class A (Child-Pugh score ≤6).
8. Life expectancy of at least 16 weeks.
9. Patients with bile duct involvement can be enrolled if patients have adequate bone marrow, liver, and renal function
10. Adequate bone marrow, liver as assessed by the following laboratory requirements (no transfusion, no restoration), conducted screening: Data can be used within 28 days of screening.

    * Hemoglobin ≥ 8.0g/dL
    * Absolute neutrophil count (ANC) ≥ 1,000/mm3
    * Platelet count ≥ 100,000/μL
    * Total bilirubin ≤ 2mg/dL
    * Serum albumin ≥ 3g/dL
    * ALT and AST \< 5 × upper limit of normal
    * PT-INR ≤ 1.7
11. Patients with involvement with tumor thrombus in the second-order branches of the portal vein or distal to the second-order branches (Vp1-Vp2) can be enrolled if operability is confirmed by the surgeon.

Exclusion Criteria:

1. Diffuse infiltrative tumor type
2. Presence of separate daughter nodule
3. Poorly defined and/or mixed-irregular tumor margin
4. Definitive combined HCC-cholangiocarcinoma on images
5. A history of receiving any systemic therapy of the molecularly targeted agents, immunotherapy, external beam radiation to the liver or cytotoxic chemotherapy for the treatment of HCC
6. Presence of extrahepatic HCC: Involvement of vessels \[major branch of hepatic vein invasion; major branch of portal vein invasion from the first order portal vein branch (Vp3) to main portal vein (Vp4)\]; lymph node, metastasis
7. History or presence of hepatic encephalopathy
8. Ascites, moderate, large or intractable
9. Active clinically serious infections (\> grade 2, NCI-CTCAE version 4.02), including spontaneous bacterial peritonitis.
10. Untreated active chronic hepatitis B
11. Esophageal or gastric varices ≥ F2 (grade 2) with red color sign positive without prophylaxis (non-selective beta-blocker or endoscopic variceal ligation) or history of variceal bleeding without endoscopic variceal ligation/ injection sclerosis
12. Active ulcer of stomach or duodenum: untreated or presence of visible vessel
13. Any major surgery within 4 weeks, or any minor surgery within 2 weeks prior to signing the informed consent form
14. Candidate for liver transplantation and/or a history of liver transplantation
15. History of cardiac diseases: congestive heart failure greater than NYHA class 2; active coronary artery disease (myocardial infarction more than 6 months prior to study entry is allowed); uncontrolled hypertension and diabetes mellitus
16. History of AIDS/HIV infection
17. Seizure disorder requiring medication (such as steroids or anti-epileptics)
18. History of organ allograft
19. Evidence or history of bleeding diathesis, or thromboembolic events requiring treatment
20. Current renal dialysis
21. Previous or concurrent cancer that has a primary site or histology distinct from HCC, except cervical carcinoma in situ, treated basal cell carcinoma, superficial bladder tumors \[Ta, Tis, and T1\] or any cancer curatively treated less than 3 years prior to enrollment.
22. (Deleted)
23. Tc-99m macroaggregated albumin (MAA) hepatic arterial perfusion scintigraphy shows any deposition to the gastrointestinal tract that may not be corrected by angiographic techniques.
24. Shunting of blood to the lungs that could result in delivery of greater than 16.5 mCi of yttrium-90 to the lungs. Radiation pneumonitis has been seen in patients receiving doses to the lungs greater than 30 Gy in a single treatment.
25. Hepatic artery catheterization is contraindicated; such as patients with vascular abnormalities or bleeding diathesis.
26. Severe liver dysfunction or pulmonary insufficiency
27. Pregnant or breast feeding women, or impossible to use of reliable methods of contraception
28. Subject who the investigator deems inappropriate to participate in this study