Clinical trial · Interventional
Testing a School-Based E-cigarette, Tobacco, and Betel (Areca) Nut Use Prevention Curriculum for Guam Youths
University of Guam/University of Hawaii Cancer Center Partnership for Cancer Health Equity, Full Project I: Developing and Testing a School-Based Curriculum for E-cigarette, Tobacco, and Betel (Areca) Nut Use Prevention for Guam Youths
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The people of the U.S. Affiliated Pacific Islands (USAPI) face higher cancer incidence, especially lung/bronchia and head-and-neck cancer, and poorer cancer outcomes, compared with the U.S. nationally. This may partly be driven by the high rates of cigarette smoking and betel (areca) nut use in the USAPI. Previous data suggest that that adolescents on Guam, as young as middle school students report markedly higher e-cigarette and tobacco product use prevalence in the USAPI compared with the USAPI nationally. Guam youths are also at risk for the use of betel nuts. Yet, currently there are no tobacco product/areca nut use prevention programs that have been developed for and tested specifically USAPI adolescents. The proposed study will develop a school-based substance use prevention curriculum for e-cigarette, tobacco product, and areca nut use prevention among Guam youths. The curriculum will use lessons incorporating innovative videos and culturally grounded activities. The study's specific aims are: 1. To develop a school-based curriculum for e-cigarette, tobacco product (i.e., cigarette, smokeless tobacco), and betel nut use prevention among middle school students in Guam. 2. Test the efficacy of the school-based curriculum in a randomized controlled trial.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Tobacco Chewing | — | UNRESOLVED | — |
| Tobacco Smoking | — | UNRESOLVED | — |
| Vaping | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| School-based curriculum | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- NO_INTERVENTION
- label
- Control
- description
- Students in the control group will receive the standard health education curriculum.
- type
- EXPERIMENTAL
- label
- Experimental
- description
- Students in the treatment group will receive the school-based classroom curriculum.
- interventionNames
- Behavioral: School-based curriculum
Primary outcomes (2)
- measure
- Changes in Youth Risk Behavior Surveillance (YRBS) Survey-based self-reported past-30-day tobacco, e-cigarette, and areca nut use
- timeFrame
- Outcomes will be assessed at baseline (pre-test), 5 weeks after baseline, immediately following curriculum/standard of care delivery (i.e., post-test), and 6 months after baseline (follow-up)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 11 Years
- Maximum age
- 15 Years
Show eligibility criteria text
Inclusion Criteria: * All students enrolled in public middle schools in Guam (age: 11-15 years old) * Provide signed parental informed consent and student assent Exclusion Criteria: * Participants whose parents decline participation or students who decline participation.
References
Publications (21)
- BACKGROUNDOkamoto SK, Helm S, Ostrowski LK, Flood L. The Validation of a School-Based, Culturally Grounded Drug Prevention Curriculum for Rural Hawaiian Youth. Health Promot Pract. 2018 May;19(3):369-376. doi: 10.1177/1524839917704210. Epub 2017 Apr 26. PMID 28443350
- BACKGROUNDOkamoto SK, Helm S, Chin SK, Hata J, Hata E, Okamura KH. The implementation of a culturally grounded, school-based, drug prevention curriculum in rural Hawai'i. J Community Psychol. 2020 May;48(4):1085-1099. doi: 10.1002/jcop.22222. Epub 2019 Jul 23. PMID 31332808
- BACKGROUNDOkamoto SK, Helm S, McClain LL, Dinson AL. The development of videos in culturally grounded drug prevention for rural native Hawaiian youth. J Prim Prev. 2012 Dec;33(5-6):259-69. doi: 10.1007/s10935-012-0281-0. PMID 23143071
- BACKGROUNDFlay BR. The promise of long-term effectiveness of school-based smoking prevention programs: a critical review of reviews. Tob Induc Dis. 2009 Mar 26;5(1):7. doi: 10.1186/1617-9625-5-7. PMID 19323827
- BACKGROUNDPokhrel P, Sussman S, Stacy A. Relative effects of social self-control, sensation seeking, and impulsivity on future cigarette use in a sample of high-risk adolescents. Subst Use Misuse. 2014 Mar;49(4):343-51. doi: 10.3109/10826084.2013.841241. Epub 2013 Oct 4. PMID 24093522
- BACKGROUNDOkamoto SK, Helm S, Pel S, McClain LL, Hill AP, Hayashida JK. Developing empirically based, culturally grounded drug prevention interventions for indigenous youth populations. J Behav Health Serv Res. 2014 Jan;41(1):8-19. doi: 10.1007/s11414-012-9304-0. PMID 23188485
- BACKGROUNDHerzog TA, Murphy KL, Little MA, Suguitan GS, Pokhrel P, Kawamoto CT. The Betel Quid Dependence Scale: replication and extension in a Guamanian sample. Drug Alcohol Depend. 2014 May 1;138:154-60. doi: 10.1016/j.drugalcdep.2014.02.022. Epub 2014 Feb 26.