Clinical trial · Observational
Verification of Harmonization of Plasma Epstein-Barr Virus DNA Measurements
Verification of Harmonization of Plasma Epstein-Barr Virus DNA Measurements at Multiple Centers in NPC Epidemic Regions
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Plasma Epstein-Barr virus (EBV) DNA will be measured in native plasma samples of nasopharyngeal carcinoma (NPC) patients, respectively, by three medical centers and a qualified laboratory in Southern China, the highest endemic area of NPC. Passing-Bablok regression and difference plots will be used to compare results from each center to the all-method median and mean values. Agreement among methods will be evaluated against bias derived from a biological variation.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Nasopharyngeal Carcinoma | Nasopharyngeal Carcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Plasma EBV DNA qPCR test | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- nasopharyngeal carcinoma patients
- description
- Plasma EBV DNA quantification by quantitative polymerase chain reaction (qPCR) assays in different medical centers.
- interventionNames
- Diagnostic Test: Plasma EBV DNA qPCR test
Primary outcomes (1)
- measure
- Plasma EBV DNA
- timeFrame
- 1 Day
- description
- copy number of EBV DNA in plasma
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: * Age between 18-70 years * Histologically confirmed NPC or Non-NPC with positive plasma cell-free EBV DNA Exclusion Criteria: * unsatisfactory performance status: Karnofsky scale (KPS) \<= 70 * Any severe intercurrent disease * Any contraindication of blood sampling
References
Publications (0)
Data not yet available