Clinical trial · Observational
13C-Glucose Tracing of Tumour and T Cells in the Ascites of Ovarian Cancer Patients.
Metabolic Tracing of Tumour and T Cells in the Ascites of Ovarian Cancer Patients
NCT05025878CI-TRIAL-00079623iMETABOunknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The objective of the study is to investigate the metabolism of cells in the ascites tumour microenvironment of ovarian cancer patients. This observational study involves intravenous infusion of \[U-13C\]glucose into patients during standard paracentesis.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Ascites | — | UNRESOLVED | — |
| Ovarian Cancer | Malignant Ovarian Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| [U-13C]Glucose | Dietary Supplement | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- [U-13C]glucose
- description
- All participants consented to the study will receive the \[U-13C\]glucose infusion and collection of ascites for research.
- interventionNames
- Dietary Supplement: [U-13C]Glucose
Primary outcomes (2)
- measure
- Achieve [U-13C]Glucose enrichment in the ascites of ovarian cancer patients
- timeFrame
- Duration of ascites paracentesis (samples collected hourly, up to 5 hours)
- description
- Extracellular \[U-13C\]Glucose label enrichment in the ascites fluid (measured by mass spectrometry).
- measure
- Compare glucose uptake and metabolic pathways in different cell populations in the ascites.
- timeFrame
- Duration of ascites paracentesis (samples collected hourly, up to 5 hours)
- description
- Fractional enrichment of intracellular \[U-13C\]Glucose and 13C labeled metabolites in T cells, myeloid cells and tumour cells (measured by mass spectrometry).
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Ovarian cancer * Any stage or grade of disease * Ascites fluid that requires draining * Any treatment regimen * Primary or recurrent ascites * Understands the concept of the study and give informed consent. Exclusion Criteria: * Participants must not have diabetes or abnormal hemoglobin A1C levels. * The patient's glucose levels must be between 4 - 11.1 mM before administering an infusion. This is to ensure that patients are within normal blood glucose levels, as described by Diabetes Canada. * Participants cannot receive chemotherapy treatment during the 5 hour duration of the experiment as it may compromise the integrity of the data.
References
Publications (0)
Data not yet available
No reference posted for this study.