Clinical trial · Interventional
The Effect of Exercise and Nicotinamide Riboside Muscle Health and Insulin Resistance in Survivors of Childhood Cancer
The Effect of Exercise and Nicotinamide Riboside on Muscle Health and Insulin Resistance in Adult Survivors of Childhood Cancer With Prediabetes: A Pilot Feasibility Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This trial studies the effect of exercise and nicotinamide riboside on muscle health and insulin resistance in adult survivors of childhood cancer with prediabetes (elevated blood sugar level that is not high enough to be considered diabetes). Nicotinamide riboside is a dietary supplement which is similar to vitamin B3. Information collected in this study may help the future development of regimens to improve metabolic outcomes such as muscle health and insulin resistance (when the body is not normally responding to insulin) in childhood cancer survivors.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hematopoietic and Lymphoid Cell Neoplasm | Hematopoietic and Lymphoid Cell Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Malignant Solid Neoplasm | Malignant Solid Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Prediabetes | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Exercise Intervention | Other | — | UNRESOLVED |
| Nicotinamide Riboside | Dietary Supplement | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Arm I (home exercise)
- description
- Patients complete 18 home exercise sessions over 30 minutes each, 3 days per weeks for 6 weeks.
- interventionNames
- Other: Exercise Intervention
- type
- EXPERIMENTAL
- label
- Arm II (home exercise, nicotinamide riboside)
- description
- Patients complete home exercise as in Arm I. Patients also receive nicotinamide riboside PO daily for 6 weeks.
- interventionNames
- Other: Exercise Intervention
- Dietary Supplement: Nicotinamide Riboside
Primary outcomes (1)
- measure
- Feasibility of a nutrition and exercise program in childhood cancer survivors (CCS)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * History of childhood cancer * History of prediabetes (HbA1c 5.7-6.4%) * In remission at time of enrollment * Time between completion of cancer-directed therapy and study entry: \>= 6 months * At least 18 years of age at time of enrollment * Able to access online exercise program at home * Ability to tolerate the prescribed resistance exercise program * English-speaking * Able to understand and sign the study specific informed consent form (ICF) Exclusion Criteria: * Taking a nicotinamide adenine dinucleotide (NAD)+ precursor in the two weeks prior to enrollment * Currently taking medication for hyperglycemia or diabetes * Females who are pregnant or planning to become pregnant * Currently recovering from an injury * Contraindication to magnetic resonance imaging (MRI) * Pacemaker
References
Publications (0)
Data not yet available