Clinical trial · Observational
PUMCH Dementia Longitudinal Cohort Study
Peking Union Medical College Hospital (PUMCH) Dementia Longitudinal Cohort Study
NCT05023564CI-TRIAL-00060821recruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The PUMCH Dementia Cohort is a hospital-based, observational study of Chinese elderly with cognitive impairment.
Conditions
Conditions (7)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Dementia | — | UNRESOLVED | — |
| Dementia Alzheimers | — | UNRESOLVED | — |
| Dementia Frontal | — | UNRESOLVED | — |
| Dementia, Mild | — | UNRESOLVED | — |
| Dementia, Mixed | — | UNRESOLVED | — |
| Dementia, Vascular | — | UNRESOLVED | — |
| Dementia With Lewy Bodies | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (4)
- label
- Early onset dementia
- description
- Dementia patients with onset age lower than 65y/o
- label
- Late onset dementia
- description
- Dementia patients with onset age between 65y/o and 85y/o
- label
- Oldest old dementia
- description
- Dementia patients with onset age older than 85y/o
- label
- Cognitive normal control
- description
- Normal Aging with normal cognitive function
Primary outcomes (18)
- measure
- The incidence of dementia
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Neurodegenerative dementia diagnosis based on 2011 NIA-AA criteria of Dementia * Fixed care giver and can follow up regularly Exclusion Criteria: * Not demented, including MCI * Systemic severe diseases and severe vision or hearing problem effecting follow up and neuropsychological evaluation * Without fixed care giver * Reject informed consent * Expected life shorter than 2 years
References
Publications (6)
- BACKGROUNDJack CR Jr, Bennett DA, Blennow K, Carrillo MC, Dunn B, Haeberlein SB, Holtzman DM, Jagust W, Jessen F, Karlawish J, Liu E, Molinuevo JL, Montine T, Phelps C, Rankin KP, Rowe CC, Scheltens P, Siemers E, Snyder HM, Sperling R; Contributors. NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease. Alzheimers Dement. 2018 Apr;14(4):535-562. doi: 10.1016/j.jalz.2018.02.018. PMID 29653606
- BACKGROUNDOlsson B, Lautner R, Andreasson U, Ohrfelt A, Portelius E, Bjerke M, Holtta M, Rosen C, Olsson C, Strobel G, Wu E, Dakin K, Petzold M, Blennow K, Zetterberg H. CSF and blood biomarkers for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis. Lancet Neurol. 2016 Jun;15(7):673-684. doi: 10.1016/S1474-4422(16)00070-3. Epub 2016 Apr 8. PMID 27068280
- BACKGROUNDNorton S, Matthews FE, Barnes DE, Yaffe K, Brayne C. Potential for primary prevention of Alzheimer's disease: an analysis of population-based data. Lancet Neurol. 2014 Aug;13(8):788-94. doi: 10.1016/S1474-4422(14)70136-X. PMID 25030513
- BACKGROUNDMcKhann GM, Albert MS, Grossman M, Miller B, Dickson D, Trojanowski JQ; Work Group on Frontotemporal Dementia and Pick's Disease. Clinical and pathological diagnosis of frontotemporal dementia: report of the Work Group on Frontotemporal Dementia and Pick's Disease. Arch Neurol. 2001 Nov;58(11):1803-9. doi: 10.1001/archneur.58.11.1803. PMID 11708987
- BACKGROUNDRosenberg A, Ngandu T, Rusanen M, Antikainen R, Backman L, Havulinna S, Hanninen T, Laatikainen T, Lehtisalo J, Levalahti E, Lindstrom J, Paajanen T, Peltonen M, Soininen H, Stigsdotter-Neely A, Strandberg T, Tuomilehto J, Solomon A, Kivipelto M. Multidomain lifestyle intervention benefits a large elderly population at risk for cognitive decline and dementia regardless of baseline characteristics: The FINGER trial. Alzheimers Dement. 2018 Mar;14(3):263-270. doi: 10.1016/j.jalz.2017.09.006. Epub 2017 Oct 19. PMID 29055814
- DERIVEDYang X, Wu M, Liang M, Zhang H, Li B, Mao C, Dong L, Wang Y, Xing H, Ren C, Huang Z, Wen Q, Ge Q, Yu Z, Feng F, Gao J, Huo L. Ultra-fast [18F]florbetapir PET imaging using the uMI Panorama PET/CT system. EJNMMI Phys. 2024 Dec 30;11(1):107. doi: 10.1186/s40658-024-00712-5.