Clinical trial · Interventional
Physical Training in Glioblastoma Patients During Cytotoxic Therapy
Glioblastoma and Sports - Does a Personal Training Program Improve Physical Performance and Quality of Life of Brain Tumor Patients
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The aim of the present study is the prospective controlled use of physical activity in a collective of patients with glioblastoma after surgery and concomitant radiation/chemotherapy and during adjuvant cytotoxic therapy. The research question is whether physical exercise is feasible and whether patients benefit physically and mentally from the activities performed. For this purpose, specific training units under the supervision of a certified trainer and sports scientist as well as standardized sports medical test procedures are implemented. Beyond the instructed training, general physical activity phases are recorded electronically using a pedometer/activity tracker, which is worn at all times. It will be examined whether the individual training program 1. improves physical fitness 2. increases quality of life/life satisfaction throughout the intervention 3. can be detected in blood due to increased concentrations of brain-derived neurotrophic factor 1 (BDNF-1) (voluntary) The measurements should be taken before and 8, 16 and 24 weeks after the start of training.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Glioblastoma | Glioblastoma | CURATED_BROADER | 0.80 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Personal Training Program | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Patients paticipating in the Personal Training Program
- description
- The study patients complete two training sessions per week (60 minutes each) under supervision (16 weeks)
- interventionNames
- Other: Personal Training Program
Primary outcomes (1)
- measure
- Increase in Physical Performance according to Physical Work Capacity (PWC) Test
- timeFrame
- Between week 0 and 16.
- description
- Evidence of a significant increase (at least 15%) in physical work \[watt/kilogram bodyweight\] at PWC75% of maximum heart rate.
Secondary outcomes (7)
- measure
- Physical Work Capacity (PWC)
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Newly diagnosed glioblastoma * Karnofsky Index ≥ 70 * Eastern Cooperative Oncology Group (ECOG) ≤ 2 * ≥ 18 years * Completed surgical therapy * Completed radiation and chemotherapy * Thrombocytes \> 50.000/µl * Hb \> 8 mg/dl * Ability to give consent * Mother tongue German/very good German skills Exclusion Criteria: * Diagnosed dementia (Mini-Mental-State-Test \< 24/30 points) * Pain (strong, permanent, restricting movement) * Impairment of consciousness * Fever * Acute infection * Pregnancy and lactation * Insufficiently adjusted epilepsy (despite anticonvulsive therapy \> 3 focal seizures per day or \> 1 generalized seizure in the previous 3 days)
References
Publications (0)
Data not yet available