Clinical trial · Observational
Thiol-disulfide Homeostasis in Patients With Ovarian Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Ovarian cancer is the third most common after endometrial and cervical cancer in societies with a high standard of living; It is the second most common type of gynecological cancer after cervical cancer in societies with a low standard of living, and it is also the deadliest among gynecological cancers. Dynamic thiol-disulfide homeostasis is an antioxidant system that minimizes oxidative damage and prevents cell damage. In the presence of oxidative stress, the thiol groups combine to form the disulfide structure, and when the oxidative stress condition is over, they are separated into thiol groups again. This homeostasis is impaired in conditions that cause oxidative processes such as diabetes, cardiovascular diseases, cancers, rheumatoid arthritis, and chronic kidney failure. This can be determined by measuring the total thiol and native thiol levels. Likewise, the level of ischemia modified albumin increases in the case of oxidative stress. There are studies on this homeostasis in the literature on many types of cancer; There are studies on endometrial cancer and cervical cancer, which are gynecological cancers In this study, the usability of these tests together with other diagnostic tests in the diagnosis of ovarian cancer will be evaluated.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Ovarian Cancer | Malignant Ovarian Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (2)
- label
- Ovarian cancer
- description
- The patients with ovarian cancer
- label
- Control group
Primary outcomes (1)
- measure
- thiol - disulfide levels
- timeFrame
- April 2021 - January 2022
- description
- the rate of total thiol, native thiol and total oxidant/antioxidant capacity
Eligibility
Eligibility (as posted)
- Sex
- Female
Show eligibility criteria text
Inclusion Criteria: * Histopathological diagnosis of ovarian cancer Exclusion Criteria: * Having an acute or chronic disease that will cause oxidative stress * Using alcohol/cigarettes/drugs * Using antioxidant agents (such as vitamins A, C, E)
References
Publications (2)
- BACKGROUNDSezgin B, Kinci MF, Pirincci F, Camuzcuoglu A, Erel O, Neselioglu S, Camuzcuoglu H. Thiol-disulfide status of patients with cervical cancer. J Obstet Gynaecol Res. 2020 Nov;46(11):2423-2429. doi: 10.1111/jog.14480. Epub 2020 Sep 9. PMID 32909381
- DERIVEDKarabulut A, Sanci M, Karatasli V, Kantarci S, Aydin Uysal A, Erel O, Neselioglu S, Ileri A. Thiol-disulfide homeostasis in ovarian cancer: comparative analysis with benign neoplasia and healthy women. Turk J Obstet Gynecol. 2026 Jun 4;23(2):160-166. doi: 10.4274/tjod.galenos.2026.55257. Epub 2026 Apr 15. PMID 41982146