Clinical trial · Interventional
Yorkshire Kidney Screening Trial
Yorkshire Kidney Screening Trial (YKST): a Feasibility Study of Adding Non-contrast Abdominal CT Scan to Chest CT Scan Undertaken in the YLST Randomised Controlled Trial of Community-based CT Screening for Lung Cancer in an at Risk Population to Screen for RCC and Other Abdominal Malignancies
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Kidney cancer is the 8th most common cancer in Yorkshire. It has a poor survival rate, with only 6 out of 10 patients diagnosed with kidney cancer still alive after 5 years. This is partly because many people with kidney cancer don't have any symptoms. In some of these people, kidney cancer is only found by chance during investigations for other reasons. In others, it is often not diagnosed until the disease has passed the point at which we can easily cure it. Screening for kidney cancer has the potential to pick up these cancers earlier and increase the number of people who can be cured. The Yorkshire Lung Screening Trial offers people aged 55-80 with a history of smoking a CT scan as part of a lung health check. This group of people is also at increased risk of developing kidney cancer. Our new study, the Yorkshire Kidney Screening Trial, will piggyback on this trial to offer an extra CT scan for kidney cancer. The extra scan will take 10 seconds. By the end of the study we will understand whether it is workable to roll this out more widely and whether people take up this extra scan.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Renal Cell Carcinoma | Renal Cell Carcinoma | CURATED_BROADER | 0.80 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Low dose abdominal computed tomography scan | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- OTHER
- label
- Abdominal CT Scan
- description
- A policy of invitation to a targeted community-based non-contrast CT screening of the abdomen in those at risk of kidney cancer.
- interventionNames
- Radiation: Low dose abdominal computed tomography scan
Primary outcomes (4)
- measure
- The proportion of individuals who take up the offer of an abdominal CT scan
- timeFrame
- At the end of the 18 month recruitment period
- description
- The proportion of individuals attending the T2 round of YLST who take up the offer of an abdominal CT scan
- measure
- The acceptability of the combined lung and RCC screening approach to participants
- timeFrame
- On completion of the patient interview analysis - by the end of the 18 month recruitment period
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 55 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion criteria As YKST will involve only consenting participants of T2 round of YLST the same inclusion criteria for the YLST Lung Health Check at the T0 stage will be used for YKST, namely: High risk for lung cancer as defined by one of the three criteria: * 30 pack year history of smoking and current smoker or quit within the last 15 years (USPSTF criteria). * Lung cancer risk of ≥1.51% over 6 years as calculated by the PLCOM2012 score. * Lung cancer risk of ≥5% over 5 years as calculated by the LLPv2. score. Exclusion Criteria: * Have undergone CT Thorax within the previous 6 months * Unable to provide informed consent to study * Unable to have a chest or abdominal non-contrast CT scan * Previous diagnosis of kidney cancer * Have undergone abdominal CT scan in previous 6 months
References
Publications (3)
- DERIVEDThomas C, Heathcote L, Sun Y, Callister MEJ, Kitt J, Rossi SH, Shinkins B, Usher-Smith JA, Whyte S, Stewart GD; YKST Study Group. Cost-effectiveness of one-off upper abdominal CT screening as an add-on to lung cancer screening in England. Br J Cancer. 2025 Aug;133(2):239-247. doi: 10.1038/s41416-025-03043-z. Epub 2025 May 14. PMID 40369122
- DERIVEDUsher-Smith JA, Masson G, Godoy A, Burge SW, Kitt J, Farquhar F, Cartledge J, Kimuli M, Burbidge S, Crosbie PAJ, Eckert C, Hancock N, Iball GR, Rogerson S, Rossi SH, Smith A, Simmonds I, Wallace T, Ward M, Callister MEJ, Stewart GD. Acceptability of adding a non-contrast abdominal CT scan to screen for kidney cancer and other abdominal pathology within a community-based CT screening programme for lung cancer: A qualitative study. PLoS One. 2024 Jul 1;19(7):e0300313. doi: 10.1371/journal.pone.0300313. eCollection 2024. PMID 38950010
- DERIVEDUsher-Smith JA, Godoy A, Burge SW, Burbidge S, Cartledge J, Crosbie PAJ, Eckert C, Farquhar F, Hammond D, Hancock N, Iball GR, Kimuli M, Masson G, Neal RD, Rogerson S, Rossi SH, Sala E, Smith A, Sharp SJ, Simmonds I, Wallace T, Ward M, Callister MEJ, Stewart GD. The Yorkshire Kidney Screening Trial (YKST): protocol for a feasibility study of adding non-contrast abdominal CT scanning to screen for kidney cancer and other abdominal pathology within a trial of community-based CT screening for lung cancer. BMJ Open. 2022 Sep 20;12(9):e063018. doi: 10.1136/bmjopen-2022-063018. PMID 36127097