Chemotherapy Combined With Camrelizumab and Apatinib in First-line Treatment of ES-SCLC

Inclusion Criteria:

* 1\. Extensive stage small cell lung cancer proved by pathology.
* 2\. Extensive small cell lung cancer does not receive systematic treatment.
* 3\. limited SCLC patients have received radiotherapy and chemotherapy for more than 6 months.
* 4\. patients have measurable lesions according to RECIST version 1.1.
* 5\. Male or female who is 18 to 75 years old.
* 6\. ECOG PS 0 or 1.
* 7\. Life expectancy is more than12 weeks.
* 8\. Appropriate organ system function.
* 9\. hyroid-stimulating hormone is ULN or less (If T3 and T4 is normal, he still meets the Inclusion Criteria even the abnormal TSH. )
* 10\. Take proper contraceptive measures.
* 11\. Subjects voluntarily participate in this study and sign the informed consent.

Exclusion Criteria:

* 1\. Previous treatment with apatinib, anti-programmed cell death (PD-1), anti-PD-1, or other PD-1/ PD-L1 immunotherapy.
* 2\. Cancer meningitis.
* 3\. patients had been diagnosed and/or treated for other malignancies within 5 years prior to enrollment, except for cured basal cell carcinoma of the skin and carcinoma in situ of the cervix.
* 4\. There are many factors affecting oral medication, such as inability to swallow, post-gastrointestinal resection, chronic diarrhea, intestinal obstruction, etc..
* 5\. Uncontrollable pleural effusion, pericardial effusion or ascites, requiring repeated drainage.
* 6\. Patients with spinal cord compression who were not cured or relieved by surgery and/or radiotherapy, or who were diagnosed with spinal cord compression after treatment and without clinical evidence of stable disease ≥1 week before enrollment;
* 7\. Patients with hypertension who cannot be well controlled by oral antihypertensive therapy, suffer from myocardial ischemia or myocardial infarction of grade I or above, arrhythmias of grade I or above , or cardiac insufficiency;
* 8\. Subjects had signs of bleeding, hemoptysis, or a history of unhealed wounds, ulcers, fractures within 2 months prior to initial administration.
* 9\. The adverse events caused by previous treatment did not completely recover.
* 10\. Patients with major surgery or obvious traumatic injury within 28 days before enrollment;
* 11\. Occurred arterial or venous thromboembolism events within 6 months.
* 12\. People with a history of drug abuse or mental disorders.
* 13\. Suffering from a serious and/or uncontrollable disease;
* 14\. Vaccination or attenuated vaccine received within 4 weeks.
* 15\. Severe allergies that require treatment with other monoclonal antibody drugs;
* 16\. Active autoimmune disease requiring systemic treatment within 2 years prior to the first administration;
* 17\. Immunosuppressive therapy with systemic or absorbable local hormones and continued for 2 weeks after the first dose;
* 18\. Participate in other anticancer drug clinical trials within 4 weeks;
* 19\. In the investigator's judgment, there are other factors that may have led to the termination of the study.