Clinical trial · Observational
Evaluation of Lymphoma Prognosis and Survivorship in Recently Diagnosed Patients, LEO Study
The Lymphoma Epidemiology of Outcomes (LEO) Cohort Study Protocol
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this infrastructure protocol is to build and maintain a large and diverse observational cohort study to support broad and cutting-edge research focused on NHL prognosis and survivorship. The LEO cohort will promote identification of clinical (including co-morbid diseases), epidemiologic (including lifestyle and other exposures), host genetic, tumor, and treatment factors that impact multiple outcomes (including event-free, overall and lymphoma-specific survival; new onset comorbidities; and patient-reported outcomes). This resource also will allow examination of the interaction among these factors in order to better understand the clinical and molecular epidemiology of outcomes in NHL. Ultimately, this approach will drive discovery and validation of treatment endpoints, improve prognostication, and identify novel approaches to improve short and long-term outcomes for NHL patients.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lymphoma, Non-Hodgkin | Non-Hodgkin Lymphoma | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Overall Survival (OS)
- timeFrame
- Time Frame: Short (<5 years), medium (5-10 years), and long-term (>10 years)
- description
- Time from date of diagnosis to date of death
Secondary outcomes (2)
- measure
- Event Free Survival (EFS)
- timeFrame
- Time Frame: Short (<5 years), medium (5-10 years), and long-term (>10 years)
- description
- Time from date of diagnosis to date of first defined event (disease progression, relapse or re-treatment for lymphoma, or death)
- measure
- Lymphoma Specific Survival (LSS)
- timeFrame
- Time Frame: Short (<5 years), medium (5-10 years), and long-term (>10 years)
- description
- Time from date of diagnosis to date of death due to lymphoma
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Newly diagnosed within 6 months (180 days) of enrollment * Patients may have been treated as long as initial non-Hodgkins Lymphoma (NHL) or Hodgkin's Lymphoma (HL) diagnosis is within 6 months of enrollment * 18 years of age or older Exclusion Criteria: * Does not meet inclusion criteria
References
Publications (0)
Data not yet available