Clinical trial · Observational
Impact of Chemotherapy on Urinary Biomarkers and Non-Invasive Urodynamics in Children
NCT04993859CI-TRIAL-00096564recruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 10, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260910-000001
Summary
Brief summary (as posted)
The over-arching aim of this study is to evaluate the effects of two specific anti-cancer chemotherapies, vincristine and doxorubicin, on bladder function and urine composition.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Bladder Dysfunction | — | UNRESOLVED | — |
| Survivors of Childhood Cancer | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Dysfunctional Voiding Symptom Score Survey (DVSS) | Other | — | UNRESOLVED |
| Non-invasive Urodynamic Test (niUDS) | Diagnostic Test | — | UNRESOLVED |
| Urinary proteomic screen | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- label
- Male Cancer Survivors with DVSS Score ≥ 9
- description
- Childhood cancer survivors treated with DOX and/or VCR with evidence of BD on DVSS
- interventionNames
- Diagnostic Test: Non-invasive Urodynamic Test (niUDS)
- Diagnostic Test: Urinary proteomic screen
- Other: Dysfunctional Voiding Symptom Score Survey (DVSS)
- label
- Female Cancer Survivors with DVSS Score ≥ 6
- description
- Childhood cancer survivors treated with DOX and/or VCR with evidence of BD on DVSS
- interventionNames
- Diagnostic Test: Non-invasive Urodynamic Test (niUDS)
- Diagnostic Test: Urinary proteomic screen
- Other: Dysfunctional Voiding Symptom Score Survey (DVSS)
- label
- Male Cancer Survivors with DVSS Score < 9
- description
- Childhood cancer survivors treated with DOX and/or VCR without evidence of BD on DVSS
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 5 Years
- Maximum age
- 13 Years
Show eligibility criteria text
Inclusion Criteria: * Children aged 5-13 years old * A history of cancer * Treatment with a chemotherapy regimen including VCR and/or DOX * Completion of chemotherapy at least one year prior to study enrollment and survey completion. Exclusion Criteria: * Patients with a: * Primary pelvic tumor * Pelvic irradiation * Pre-existing bladder/bowel dysfunction * Spinal defects * Neurologic disorder * Neuro-oncologic tumor or brain metastasis * Cyclophosphamide or ifosfamide therapy
References
Publications (0)
Data not yet available
No reference posted for this study.