Clinical trial · Interventional
Impact of Total Intravenous Anesthesia Following Cancer Surgery, TIVACS Study
The Impact of Total Intravenous Anesthesia Following Cancer Surgery (TIVACS) Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Principal investigator departed sponsoring organization
Summary
Brief summary (as posted)
This phase II trials studies the impact of total intravenous anesthesia (TIVA) following cancer surgery. Surgery and the anesthesia delivered causes physiologic stress and trauma resulting in immune suppression. TIVA is an alternative method of general anesthesia that has several benefits over volatile inhalation agents such as reducing nausea, vomiting, and opioid consumption, and promotes earlier return of bowel function following surgery. In addition, TIVA is less immunosuppressive than inhalational agents and has been shown to decrease cancer cell proliferation, migration, and metastasis formation. Giving TIVA during cancer-directed abdominal surgery may decrease the immunosuppressive state in the peri-surgical period.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pancreatic Adenocarcinoma | Pancreatic Adenocarcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Anesthesia Procedure | Procedure | — | UNRESOLVED |
| General Anesthesia Procedure | Drug | — | UNRESOLVED |
| Resection | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Arm I (surgical resection with TIVA)
- description
- Patients undergo surgical resection with TIVA.
- interventionNames
- Procedure: Anesthesia Procedure
- Procedure: Resection
- type
- ACTIVE_COMPARATOR
- label
- Arm II (surgical resection with inhaled volatile anesthetics)
- description
- Patients undergo surgical resection with inhaled volatile anesthetics.
- interventionNames
- Drug: General Anesthesia Procedure
- Procedure: Resection
Primary outcomes (1)
- measure
- Impact of Anesthetic Agent on Inflammation and Immunosuppression
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Adults: ≥18 years old on the day of consent * Non-metastatic pancreatic adenocarcinoma * Able to provide consent * ECOG performance status of 0 or 1 * Women of childbearing potential (WOCBP) must have a negative urine or serum pregnancy test for the patient at the time of surgery. * Ability to understand and the willingness to sign a written informed consent document. Exclusion Criteria: * Previous identified allergy or hypersensitivity to any component of the study treatment * Allergies to eggs, egg products, soybeans, or soy products * Personal or first degree relative with a history of malignant hyperthermia * Has a known additional malignancy that is expected to require active treatment within two years, or is likely to be life-limiting in the opinion of the treating investigator. Superficial bladder cancer, non-melanoma skin cancers, or low-grade prostate cancer not requiring therapy would not exclude participation in this trial. * Uncontrolled intercurrent illness including, but not limited to: Symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements. * Pregnant or lactating females * Major surgery within 2 months before enrollment. Complete healing from major surgery must have occurred 1 month before enrollment. Complete healing from minor surgery (eg, simple excision, tooth extraction) must have occurred at least 7 days before enrollment. Subjects with clinically relevant complications from prior surgery are not eligible. * Patients who undergo reoperation during their initial hospitalization will be censored at the time of reoperation. * Prisoner status
References
Publications (0)
Data not yet available